Trial reportThe New England journal of medicine2020
Janus Kinase Inhibition in the Aicardi-Goutières Syndrome.
Abstract readClinical TrialLetter
In one paragraph
Trial report in The New England journal of medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
109 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The 2021 European Alliance of Associations for Rheumatology/American College of Rheumatology points to consider for diagnosis and management of autoinflammatory type I interferonopathies: CANDLE/PRAAS, SAVI and AGS.Annals of the rheumatic diseases · 2022Pooled it
- Effectiveness and Safety of JAK Inhibitors in Autoinflammatory Diseases: A Systematic Review.Frontiers in medicine · 2022Pooled it
- Efficacy and safety of baricitinib in Japanese patients with autoinflammatory type I interferonopathies (NNS/CANDLE, SAVI, And AGS).Pediatric rheumatology online journal · 2023Trial
- Severe hematopoietic stem cell inflammation compromises chronic granulomatous disease gene therapy.Cell reports. Medicine · 2023Trial
- Neonatal Aicardi-Goutières syndrome presenting with macrophage activation syndrome-like hyperinflammation and severe congenital glaucoma: a case report.Pediatric rheumatology online journal · 2026Article
- Familial pulmonary alveolar proteinosis and type I interferonopathy by mutation of STAT2 (TIMS2).The Journal of experimental medicine · 2026Article
- Movement Disorders in Aicardi-Goutières Syndrome and Response to Immunomodulation.Annals of clinical and translational neurology · 2026Article
- Type I Interferonopathies: Fifteen Years On, From Concept to Therapeutic Perspectives.Current rheumatology reports · 2026Review
- Therapeutic targeting of the cGAS-STING pathway in human disease.The Journal of clinical investigation · 2026Review
- "CANDLE syndrome: A closer look at a rare autoinflammatory disorder".Journal of translational autoimmunity · 2026Review
- Autoinflammatory syndromes of STING and TREX1 dysfunction.The Journal of clinical investigation · 2026Review
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Article
- Design of a Pediatric Low Motor Function Item Battery in leukodystrophies.Molecular genetics and metabolism · 2026Article
- A novel patient-Centered approach to clinical trial readiness in rare diseases: Application in Aicardi-Goutières Syndrome (AGS).Molecular genetics and metabolism · 2026Article
- HeterozygousiScience · 2026Article
- [Interferon scores in the management of rheumatic systemic diseases].Zeitschrift fur Rheumatologie · 2026Review
- Article
- Gut metabolites identified in cerebrospinal fluid of genetic interferonopathy support gut-brain endothelial dysfunction.Clinical & translational immunology · 2026Article
- Beyond the interferon score: neurofilament light chain and glial fibrillary acidic protein capture immune-mediated neuroinjury and response to JAK inhibition in Aicardi-Goutières syndrome.Frontiers in immunology · 2026Article
49 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
27 authors.
Adeline VanderverChildren's Hospital of Philadelphia, Philadelphia, PA vandervera@email.chop.edu.
Laura AdangChildren's Hospital of Philadelphia, Philadelphia, PA vandervera@email.chop.edu.ORCID 0000-0002-8454-1116
Francesco GavazziChildren's Hospital of Philadelphia, Philadelphia, PA vandervera@email.chop.edu.
Katherine McDonaldChildren's Hospital of Philadelphia, Philadelphia, PA vandervera@email.chop.edu.
Guy HelmanRoyal Children's Hospital Melbourne, Melbourne, VIC, Australia.
David B FrankChildren's Hospital of Philadelphia, Philadelphia, PA.
Nicole JaffeChildren's Hospital of Philadelphia, Philadelphia, PA.
Sabrina W YumChildren's Hospital of Philadelphia, Philadelphia, PA.
Abigail CollinsChildren's Hospital Colorado, Aurora, CO.
Stephanie R KellerChildren's Healthcare of Atlanta, Atlanta, GA.
Pierre LebonFaculté de Médecine Université Paris Descartes, Paris, France.
Jean-François MeritetHôpital Cochin, Paris, France.
Jullie RheeChildren's National Health System, Washington, DC.
Asako TakanohashiChildren's Hospital of Philadelphia, Philadelphia, PA.
Thais ArmangueSant Joan de Déu Children's Hospital, Barcelona, Spain.
Nicole UlrickChildren's Hospital of Philadelphia, Philadelphia, PA.
Omar SherbiniChildren's Hospital of Philadelphia, Philadelphia, PA.
Jamie KohChildren's Hospital of Philadelphia, Philadelphia, PA.
Kyle PeerChildren's Hospital of Philadelphia, Philadelphia, PA.
Constance BesnierChildren's Hospital of Philadelphia, Philadelphia, PA.
Carly ScherChildren's Hospital of Philadelphia, Philadelphia, PA.
Katherine BoyleChildren's Hospital of Philadelphia, Philadelphia, PA.
Holly DubbsChildren's Hospital of Philadelphia, Philadelphia, PA.
Julia Kramer-GolinkoffChildren's Hospital of Philadelphia, Philadelphia, PA.
Amy PizzinoChildren's Hospital of Philadelphia, Philadelphia, PA.
Sarah WoidillChildren's Hospital of Philadelphia, Philadelphia, PA.
Justine ShultsUniversity of Pennsylvania, Philadelphia, PA.
Funding
Validation of the GMFC-MLDU54NS115052 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI Laura Ann Adang, FLORIAN S EICHLER · 2019 to 2026
$14.3MInstitutional Clinical and Translational Science AwardKL2TR001879 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI MEAGHER, EMMA ANNE · 2016 to 2025
$13.7MClinical Outcomes in Aicardi Goutières SyndromeU01NS106845 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI VANDERVER, ADELINE LUCIE · 2019 to 2023
$7.5MReverse Transcriptase Inhibitors in Aicardi Goutieres SyndromeU01HD082806 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI VANDERVER, ADELINE LUCIE · 2015 to 2018
$1.6MClinical measures in Aicardi Goutieres SyndromeK23NS114113 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ADANG, LAURA ANN · 2019 to 2023
$947kWnt-mediated epithelial-endothelial crosstalk in the generation and regeneration of the lung alveolusK08HL140129 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI FRANK, DAVID BRIAN · 2018 to 2022
$797kEli Lilly and Company sponsor of the expanded access program for baricitNCATS NIH HHS KL2 TR001879NHLBI NIH HHS K08 HL140129NICHD NIH HHS U01 HD082806NINDS NIH HHS K23 NS114113NINDS NIH HHS U01 NS106845NINDS NIH HHS U54 NS115052
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdolescentAge of OnsetAutoimmune Diseases of the Nervous SystemAzetidinesBiomarkersChildChild DevelopmentChild, PreschoolDose-Response Relationship, DrugFemaleGene ExpressionHumansInfantInterferonsJanus Kinase InhibitorsLeast-Squares AnalysisAzetidinesbaricitinibBiomarkersInterferonsJanus Kinase InhibitorsPurinesPyrazolesSulfonamides
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.