ArticlePloS one2020
Predictive value of serum albumin-to-globulin ratio for incident chronic kidney disease: A 12-year community-based prospective study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Radiomics analysis of contrast-enhanced CT for staging liver fibrosis: an update for image biomarker.Hepatology international · 2022Trial
- Linking systemic inflammation to periodontal disease: insights from blood-derived biomarkers in NHANES.Odontology · 2026Article
- Prognostic Value of Albumin/Globulin Ratio for Mortality in Stage 2 Cardiovascular-Kidney-Metabolic Syndrome: A Nationwide Cohort Analysis (1999-2018).High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Albumin-to-Globulin Ratio as a Predictor of Disease Severity in Emergency Department Patients Presenting with Flank Pain.International journal of general medicine · 2026Article
- Serum Albumin Level Predicts Systemic Arterial Stiffening Mediated Partially by Change in Lean Body Mass: A Retrospective Cohort Study in General Japanese Population.Vascular health and risk management · 2026Article
- Laboratory, Clinical, and Pathohistological Significance of the Outcomes of Patients with Membranous Nephropathy After 10 Year of Follow-Up.Life (Basel, Switzerland) · 2025Article
- Albumin-to-Globulin ratio as an independent risk factor for predicting prognostic risk in patients with acute coronary syndrome undergoing percutaneous coronary intervention.BMC cardiovascular disorders · 2025Article
- Effect of Non-Ionizing Radiations on Liver and Kidney Function Tests in an Animal Model.Journal of biomedical physics & engineering · 2025Article
- Systemic immune-inflammation Index is associated with chronic kidney disease in the U.S. population: insights from NHANES 2007-2018.Frontiers in immunology · 2024Article
- Serum Globulin and Albumin-to-Globulin Ratio are Associated with Diabetic Kidney Disease but Not Diabetic Retinopathy in Type 2 Diabetes Mellitus Patients: A Cross-Sectional Study.Journal of inflammation research · 2024Article
- Association of serum albumin to globulin ratio with outcomes in acute ischemic stroke.CNS neuroscience & therapeutics · 2023Article
- Combination of albumin-to-globulin ratio and plasma fibrinogen is a sensitive tool for preoperative screening of infected nonunion in patients undergoing reoperation after open reduction and internal fixation: a retrospective study.Journal of orthopaedic surgery and research · 2022Article
- Protective role of antithrombin III in suppressing acute responses in a rat model of renal ischemia-reperfusion injury.Molecular and cellular biochemistry · 2022Article
- Serum Albumin to Globulin Ratio is Associated with the Presence and Severity of Inflammatory Bowel Disease.Journal of inflammation research · 2022Article
- Active Yeast but Not Henhouse Environment Affects Dropping Moisture Levels in Egg-Laying Hens.Animals : an open access journal from MDPI · 2021Article
- Prediction of Treatment Outcome with Inflammatory Biomarkers after 2 Months of Therapy in Pulmonary Tuberculosis Patients: Preliminary Results.Pathogens (Basel, Switzerland) · 2021Article
- Association between serum albumin-to-globulin ratio and diabetic retinopathy: A cross-sectional study based on the 2001-2020 NHANES database.Science progressArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammation plays a pivotal role in the pathogenesis of chronic kidney disease (CKD). Significant association between serum albumin-to-globulin (AG) ratio and inflammation led us to investigate the prognostic value of serum AG ratio for incident CKD.
methodsThe predictive value of serum AG ratio, white blood cell (WBC), and C-reactive protein (CRP) for CKD development was assessed in 8,057 non-CKD participants from a community-based, prospective cohort in Korea. Serum AG ratio was calculated by following equation: serum albumin (g/L)/[serum total protein (g/L)-serum albumin (g/L)]. Incident CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m2 and/or proteinuria of more than 1+ on dipstick.
resultsMedian serum AG ratio was 1.38 (interquartile range, 1.28-1.52). During a mean follow-up duration of 9.1±3.7 years, 1,732 participants (21.5%) developed CKD. In a multivariable Cox analysis, a low serum AG ratio was significantly associated with an increased risk of incident CKD (Q1, serum AG ratio <1.26: hazard ratio [HR] = 1.651, 95% confidence interval [CI] = 1.406-1.938, Q5 as reference; per 0.2 decrease, HR = 1.170, 95% CI = 1.109-1.234). Serum AG ratio was the only indicator to improve the predictability of CKD development (net reclassification index = 0.158, P <0.001; integrated discrimination improvement = 0.005, P <0.001), compared with WBC or CRP.
conclusionsThis study demonstrates that low serum AG ratio is an independent predictor for CKD development and exhibits a stronger predictive value than other inflammatory markers. These findings suggest that determining serum AG ratio may be more valuable for predicting adverse kidney outcomes in non-CKD populations.
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