ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020
Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.
- Incidence and factors independently associated with acute respiratory distress syndrome in chinese patients with severe acute pancreatitis: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Prognostic significance of heart rate trajectories on organ failure in predicted severe acute pancreatitis: secondary analysis of a randomized trial.Scientific reports · 2026Trial
- Trial
- Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality.Scientific reports · 2021Trial
- The impact of fluid resuscitation via colon on patients with severe acute pancreatitis.Scientific reports · 2021Trial
- A Bar-Based Nomogram for Predicting Septic Shock in Patients with Acute Pancreatitis Complicated by Sepsis: Development and External Validation.Shock (Augusta, Ga.) · 2026Article
- New Perspectives in the Assessment of Severity Scoring in Acute Pancreatitis: Development and Internal Validation of a Novel Bedside Prognostic Score (ProbScore2).Medicina (Kaunas, Lithuania) · 2026Observational
- Multiple organ dysfunction syndrome: molecular mechanisms and therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- A time-series feature-based nomogram for the prediction of severe acute pancreatitis.BMC gastroenterology · 2026Article
- Hypovolemic Shock in the Setting of Third Spacing with Concentric Left Ventricular Hypertrophy: A Physiology-Guided Management of Fluid Resuscitation-Case Report and Literature Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Heart failure with preserved ejection fraction beyond the heart: exploring the heart-liver-pancreas axis.ESC heart failure · 2026Review
- Prognostic analysis of acute pancreatitis due to different etiologies and establishment and validation of an early prediction model.Lipids in health and disease · 2026Article
- Comparative Evaluation of the Prognostic Accuracy of IL-6 and Angiopoietin-2 for Early Severity Assessment in Acute Pancreatitis: A Systematic Review.Diseases (Basel, Switzerland) · 2026Review
- Predicting the acute pancreatitis severity with multi-machine learning models: constructing an online prediction platform.Frontiers in cellular and infection microbiology · 2026Article
- Multisystem laboratory changes before and after blood purification in acute pancreatitis: a real-world descriptive analysis of 141 cases.Frontiers in medicine · 2026Article
- An explainable machine learning framework integrating clinical and lipidomic signatures for early severity stratification of hypertriglyceridemic pancreatitis.Frontiers in medicine · 2026Article
- Association of fluid balance trajectories and cumulative fluid balance with in-hospital mortality in patients with acute pancreatitis.Frontiers in medicine · 2026Article
- Relationship Between Blood Urea Nitrogen to Albumin Ratio and Risks of Mortality and Delirium in Pancreatitis Patients: A Retrospective Analysis of the MIMIC-IV Database.Gastroenterology research and practice · 2026Article
- Exploring the Mechanism of Therapeutic Effects of Polydatin in Lung Ischemia-Reperfusion Injury by Network Pharmacology and Experiment Validation.Journal of inflammation research · 2026Article
- Osmolarity trajectories and outcomes in patients with acute pancreatitis in the intensive care unit: group-based trajectory modeling.BMC medical informatics and decision making · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute pancreatitis (SAP) includes persistent systemic inflammation (SIRS) and multiorgan failure (MOF). The mechanism of transition from SIRS to MOF is unclear. We developed a fluid compartment model and used clinical data to test predictions. The model includes vascular, interstitial and "third-space" compartments with variable permeability of plasma proteins at the capillaries. Consented patients from University of Pittsburgh Medical Center Presbyterian Hospital were studied. Preadmission and daily hematocrit (HCT), blood urea nitrogen (BUN), creatine (Cr), albumin (Alb), and total protein (TP) were collected, and nonalbumin plasma protein (NAPP = TP minus the Alb) was calculated. Subjects served as their own controls for trajectory analysis. Of 57 SAP subjects, 18 developed MOF (5 died), and 39 were non-MOF (0 died). Compared with preadmission levels, admission HCT increased in MOF +5.00 [25%-75% interquartile range, IQR] versus non-MOF -0.10 [-1.55, 1.40] (
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