Evidence map›Paper›PMID 32877213›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis.

Xue Chen, George K Acquaah-Mensah, Krista L Denning, Jonathan M Peterson, Kesheng Wang, James Denvir, Feng Hong, Arthur I Cederbaum, Yongke Lu

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Xue ChenDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
George K Acquaah-MensahDepartment of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Worcester, Massachusetts.
Krista L DenningDepartment of Pathology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Jonathan M PetersonDepartment of Health Sciences, College of Public Health, East Tennessee State University, Johnson City, Tennessee.
Kesheng WangDepartment of Family and Community Health, School of Nursing, Health Sciences Center, West Virginia University, Morgantown, West Virginia.
James DenvirDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Feng HongInstitute of Liver Diseases, Affiliated Hospital of Jining Medical University, Jining, China.
Arthur I CederbaumDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Yongke LuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia.
Marshall University · USAffiliated Hospital of Jining Medical University · CNEast Tennessee State University · USIcahn School of Medicine at Mount Sinai · USMCPHS University · USWest Virginia University · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI JUDITH FEINBERG · 2012 to 2026
$81.0M
Regulation of Tight Junction Molecular Composition by Na/K-ATPaseP20GM121299 · NIGMS · MARSHALL UNIVERSITY · PI HAYNES, JENNIFER · 2018 to 2022
$10.6M
Nicotine and Alcoholic Liver DiseaseR01AA024723 · NIAAA · MARSHALL UNIVERSITY · PI LU, YONGKE · 2016 to 2020
$1.8M
Liver-Adipose tissue crosstalk in NAFLD: Role of the Novel Adipokine CTRP3R15DK114740 · NIDDK · EAST TENNESSEE STATE UNIVERSITY · PI CLARK, WILLIAM ANDREW · 2018 to 2018
$444k
HHS | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAA) AA-024723NIAAA NIH HHS R01 AA024723NIDDK NIH HHS R15 DK114740NIGMS NIH HHS P20 GM121299NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Obesity is linked to nonalcoholic steatohepatitis. Peroxisome proliferator-activated receptor-α (PPARα) regulates lipid metabolism. Cytochrome

Indexed as

AnimalsAryl Hydrocarbon HydroxylasesBody WeightCytochrome P450 Family 2Diet, High-FatLipid DropletsLipid PeroxidationLiver CirrhosisMaleMiceMice, Inbred C57BLMice, KnockoutNon-alcoholic Fatty Liver DiseasePPAR alphaAryl Hydrocarbon HydroxylasesCyp2a5 protein, mouseCytochrome P450 Family 2PPAR alpha3-NTcholineCYP2E1IL-1βlipid peroxidation

Identifiers

PMID32877213
PMCPMC8087345
OpenAlexW3082574252

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.