ArticlePlant biotechnology journal2021
Rice NIN-LIKE PROTEIN 4 plays a pivotal role in nitrogen use efficiency.
Article in Plant biotechnology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 143 citations in OpenAlex.
- Progress and new questions in understanding the mechanisms controlling plant nitrogen responses.Plant biotechnology (Tokyo, Japan) · 2026Article
- Optimization of carbon and nitrogen utilization for enhanced photosynthesis, biomass and yield by coexpression of phosphoenolpyruvate carboxylase, aspartate aminotransferase and glutamine synthetase in Brassica juncea.Plant biotechnology journal · 2026Article
- Physiological and Molecular Mechanisms of Nitrogen Regulation on Grain Quality in Cereal Crops at Later Stages.International journal of molecular sciences · 2026Review
- The transcription factor OsMADS61 positively regulates root elongation and nitrogen use efficiency in rice.Plant communications · 2026Article
- Improving nitrogen use efficiency ofFrontiers in plant science · 2026Article
- NRT1.1 as central signaling hub orchestrating plant growth and stress trade-offs.Frontiers in plant science · 2026Review
- High-throughput screening for biostimulant discovery: opportunities to enhance nitrogen use efficiency.Frontiers in plant science · 2026Review
- Enhancing cereal productivity via nitrogen use efficiency: from conventional breeding to modern genomics.Frontiers in genetics · 2026Review
- Homeostasis of ammonium and nitrate in plants.Quantitative plant biology · 2026Review
- Article
- Genome-wide association studies for identification of QTLs and key candidate genes to improve grain quality in rice (Food chemistry. Molecular sciences · 2025Article
- Exploring the Effects ofPlants (Basel, Switzerland) · 2025Article
- The NLP-HSF regulatory module contributes to nitrogen-mediated thermotolerance in rice.Plant communications · 2025Article
- Article
- Genome-Wide Identification and Expression Analysis of the NLP Family in Sweet Potato and Its Two Diploid Relatives.International journal of molecular sciences · 2025Article
- Nature variations of OsNLP4 responsible for nitrogen use efficiency divergence in the two rice subspecies.Nature communications · 2025Article
- OsRF2b interacting with OsbZIP61 modulates nitrogen use efficiency and grain yield via heterodimers in rice.Plant biotechnology journal · 2025Article
- Chromatin accessibility dynamics and transcriptional regulatory networks underlying the primary nitrogen response in rice roots.Plant communications · 2025Article
- 9311 allele of OsNAR2.2 enhances nitrate transport to improve rice yield and nitrogen use efficiency.Plant biotechnology journal · 2025Article
- Translational insights into abiotic interactions: From Arabidopsis to crop plants.The Plant cell · 2025Review
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Authors and funding
20 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nitrogen (N) is one of the key essential macronutrients that affects rice growth and yield. Inorganic N fertilizers are excessively used to boost yield and generate serious collateral environmental pollution. Therefore, improving crop N use efficiency (NUE) is highly desirable and has been a major endeavour in crop improvement. However, only a few regulators have been identified that can be used to improve NUE in rice to date. Here we show that the rice NIN-like protein 4 (OsNLP4) significantly improves the rice NUE and yield. Field trials consistently showed that loss-of-OsNLP4 dramatically reduced yield and NUE compared with wild type under different N regimes. In contrast, the OsNLP4 overexpression lines remarkably increased yield by 30% and NUE by 47% under moderate N level compared with wild type. Transcriptomic analyses revealed that OsNLP4 orchestrates the expression of a majority of known N uptake, assimilation and signalling genes by directly binding to the nitrate-responsive cis-element in their promoters to regulate their expression. Moreover, overexpression of OsNLP4 can recover the phenotype of Arabidopsis nlp7 mutant and enhance its biomass. Our results demonstrate that OsNLP4 plays a pivotal role in rice NUE and sheds light on crop NUE improvement.
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