Evidence map›Paper›PMID 32876941›Full record

ArticleAging clinical and experimental research2020

Evidence for possible association of vitamin D status with cytokine storm and unregulated inflammation in COVID-19 patients.

Ali Daneshkhah, Vasundhara Agrawal, Adam Eshein, Hariharan Subramanian, Hemant Kumar Roy, Vadim Backman

Erratum issued Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT04519034 (Retrospective Pilot Study of Vitamin D Status and Immune-inflammatory Status in Different UK Populations With COVID-19 Infection), which is not on this map. Cited by 97 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed, 13 pooled it
19.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04519034 completednot on this map

Retrospective Pilot Study of Vitamin D Status and Immune-inflammatory Status in Different UK Populations With COVID-19 Infection

TypeobservationalSponsorGuy's and St Thomas' NHS Foundation TrustRan2020 to 2021Enrolled27,628ConditionsCovid19Armsno intervention
3 · Its place in the literature

Who cites it

97 citing papers in PubMed, 13 syntheses or guidelines pooled it, 166 citations in OpenAlex.

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  10. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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37 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ali DaneshkhahDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Vasundhara AgrawalDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Adam EsheinDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Hariharan SubramanianDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Hemant Kumar RoyBoston Medical Center, Boston, MA, USA.
Vadim BackmanDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA. v-backman@northwestern.edu.ORCID http://orcid.org/0000-0003-1981-1818
Northwestern University · USBoston Medical Center · US

Funding

Translating buccal nanocytology for lung cancer screening into clinical practiceR01CA225002 · NCI · NORTHWESTERN UNIVERSITY · PI Vadim Backman, HARIHARAN SUBRAMANIAN · 2018 to 2026
$5.0M
NCI NIH HHS R01 CA225002
6 · The paper itself

Abstract

objectivesWe present evidence for a possible role of Vitamin D (VitD) deficiency in unregulated cytokine production and inflammation leading to complications in COVID-19 patients.

designThe time-adjusted case mortality ratio (T-CMR) was estimated as the ratio of deceased patients on day N to the confirmed cases on day N-8. The adaptive average of T-CMR (A-CMR) was calculated as a metric of COVID-19 associated mortality. A model based on positivity change (PC) and an estimated prevalence of COVID-19 was used to determine countries with similar screening strategies. A possible association of A-CMR with the mean concentration of 25-hydroxyvitamin D (25(OH)D) in elderly individuals in countries with similar screening strategy was investigated. We considered high C-reactive protein (CRP) in severe COVID-19 patients (CRP ≥ 1 mg/dL) as a surrogate of a cytokine storm. We considered high-sensitivity CRP (hs-CRP) in healthy subjects as hs-CRP ≥ 0.2 mg/dL.

resultsA link between 25(OH)D and A-CMR in countries with similar screening strategy is evidence for VitD's possible role in reducing unregulated cytokine production and inflammation among patients with severe COVID-19. We observed an odds ratio (OR) of 1.8 with 95% confidence interval (95% CI) (1.2 to 2.6) and an OR of 1.9 with 95% CI (1.4 to 2.7) for hs-CRP in VitD deficient elderly from low-income families and high-income families, respectively. COVID-19 patient-level data show an OR of 3.4 with 95% CI (2.15 to 5.4) for high CRP in severe COVID-19 patients.

conclusionWe conclude that future studies on VitD's role in reducing cytokine storm and COVID-19 mortality are warranted.

Indexed as

AgedBetacoronavirusCoronavirus InfectionsCOVID-19C-Reactive ProteinCytokinesFemaleHumansInflammationMaleMiddle AgedPandemicsPneumonia, ViralSARS-CoV-2Vitamin DC-Reactive ProteinCytokinesVitamin DCase mortality ratioCOVID-19C-reactive proteinCytokine stormSARS-CoV-2Vitamin D

Identifiers

PMID32876941
PMCPMC7465887
OpenAlexW3082950251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.