ArticleJournal of nephrology2021
Ex vivo confocal microscopy performs real-time assessment of renal biopsy in non-neoplastic diseases.
Article in Journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Instant confocal histology for the evaluation of kidney transplant procurement biopsies.Virchows Archiv : an international journal of pathology · 2025Article
- [Digital pathology using ex vivo confocal laser scanning microscopy].Dermatologie (Heidelberg, Germany) · 2025Review
- Ex Vivo Fluorescence Confocal Microscopy Meets Innovation and Revolutionary Technology, for "Real-Time" Histological Evaluation, in Pediatric Surgical Oncology.Children (Basel, Switzerland) · 2024Article
- Fast Green FCF Improves Depiction of Extracellular Matrix in Ex Vivo Fluorescence Confocal Microscopy.Life (Basel, Switzerland) · 2024Article
- Virtual Staining of Nonfixed Tissue Histology.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2024Review
- The Puzzle of Preimplantation Kidney Biopsy Decision-Making Process: The Pathologist Perspective.Life (Basel, Switzerland) · 2024Review
- Artificial Intelligence in Surgical Training for Kidney Cancer: A Systematic Review of the Literature.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- A two-stage renal disease classification based on transfer learning with hyperparameters optimization.Frontiers in medicine · 2023Article
- New imaging technologies for robotic kidney cancer surgery.Asian journal of urology · 2022Review
- In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment.Journal of biomedical optics · 2022Article
- Ex Vivo Fluorescence Confocal Microscopy in Specimens of the Liver: A Proof-of-Concept Study.Cancers · 2022Article
- Exploring the utility of Deep Red Anthraquinone 5 for digital staining of ex vivo confocal micrographs of optically sectioned skin.Journal of biophotonics · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundEx vivo confocal microscopy is a technique for tissue examination, which generates images of fresh samples with an optical resolution comparable to those obtained by conventional pathology. The objective of this study was to evaluate the feasibility of using ex vivo confocal microscopy in fusion mode (reflectance and fluorescence) and the H&E-like digital staining that is obtained for the analysis of non-neoplastic kidney biopsies.
methodsTwenty-four renal samples acquired from autopsies were scanned in a 4th generation ex vivo confocal microscopy device. The imaging process was completed in an average of three minutes.
resultsConfocal images correlated very well to the corresponding conventional histological sections, both in normal tissue and in chronic lesions (glomerulosclerosis, fibrosis and tubular atrophy). The ex vivo confocal microscopy protocol did not add artifacts to the sample for the ulterior study with light microscopy, nor to the histochemical or immunohistochemical studies.
conclusionThe ease and speed of grayscale and fluorescence image acquisition, together with the quality of the H&E-like digitally stained images obtained with this approach, suggest that this technique shows promise for use in clinical nephrology and renal transplantation.
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