ReviewDrugs2020
Post-Thoracotomy Pain: Current Strategies for Prevention and Treatment.
Review in Drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06750627 (Efficacy of Continuous Erector Spinae Plane Block to Reduce Postoperative Pain in Patients Undergoing Unilateral Thoracotomy), which is not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy of Continuous Erector Spinae Plane Block to Reduce Postoperative Pain in Patients Undergoing Unilateral Thoracotomy
Who cites it
29 citing papers in PubMed.
- Modified Single-Side-Lying Quadratus Lumborum Block Combined with Liposomal Bupivacaine versus Transversus Abdominis Plane Block for Post-Cesarean Analgesia: A Randomized Controlled Trial.Drug design, development and therapy · 2026Trial
- Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial.International journal of clinical pharmacy · 2025Trial
- Paracetamol did not improve the analgesic efficacy with regional block after video assisted thoracoscopic surgery: a randomized controlled trial.BMC anesthesiology · 2025Trial
- The Scalp Nerve Block Combined with Intercostal Nerve Block Improves Recovery After Deep Brain Stimulation in Patients with Parkinson's Disease: A Prospective, Randomized Controlled Trial.Clinical interventions in aging · 2024Trial
- Music therapy for pain and anxiety in patients after cardiac valve replacement: a randomized controlled clinical trial.BMC cardiovascular disorders · 2023Trial
- Pain management strategies following thoracic surgery: best practices and innovations.Journal of thoracic disease · 2026Review
- A Clinical nomogram for predicting chronic postsurgical pain in patients undergoing video-assisted thoracoscopic surgery.BMC surgery · 2026Article
- Unlocking patient insights: a prospective study on patient reported outcome measures in thoracic surgery.Journal of cardiothoracic surgery · 2026Observational
- Botulinum toxin type A inhibits chronic post-thoracotomy pain through the HMGB1-mediated TLR4/NF-κB signaling pathway.American journal of translational research · 2026Article
- Inhibition of mPFC norepinephrine improved chronic post-thoracotomy pain in adult rats.Annals of medicine · 2025Article
- Multimodal Anesthesia-Analgesia for Patients with Huntington's Disease: A Case Series.Acta medica academica · 2025Article
- Analysis of factors associated with intercostal neuralgia after osteoporotic thoracic spine fracture and construction of a prediction model.BMC musculoskeletal disorders · 2025Article
- Risk factors for chronic postsurgical pain following minimally invasive thoracic surgery.Frontiers in surgery · 2025Article
- Efficacy of esketamine for chronic post-thoracotomy pain: protocol for a systematic review and meta-analysis.BMJ open · 2024Article
- Ultrasound-guided perineural intercostal autologous platelet-rich plasma in the treatment of chronic post-thoracotomy pain syndrome - A prospective case series.Interventional pain medicine · 2024Article
- Postoperative Dexmedetomidine Infusion and Chronic Postsurgical Pain in Thoracoscopic Pulmonary Nodule Surgery: A Retrospective Study with Propensity-Score-Matched Analysis.Pain and therapy · 2024Article
- Chronic Postsurgical Pain Following Lung Transplantation: Characteristics, Risk Factors, Treatment, and Prevention: A Narrative Review.Pain and therapy · 2024Review
- Administration of flurbiprofen axetil and dezocine for the postoperative analgesia in patients with non‑small cell lung cancer: A randomized, controlled study.Oncology letters · 2024Article
- Comparison of analgesic effects of percutaneous and transthoracic intercostal nerve block in video-assisted thoracic surgery: a propensity score-matched study.Journal of cardiothoracic surgery · 2024Article
- Post-Operative Thoracic Epidural Analgesia and Incidence of Major Complications according to Specific Safety Standardized Documentation: A Large Retrospective Dual Center Experience.Journal of personalized medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treating acute pain after thoracotomy surgery and preventing the development of chronic post-thoracotomy pain syndrome (PTPS) remain significant challenges in this surgical population. While appropriately treated acute thoracotomy pain often resolves, a significant number of patients develop PTPS, with up to 65% of patients experiencing some pain and 10% suffering life-altering, debilitating pain. Currently, there is very little known about specific molecular targets or novel therapeutic combinations that effectively prevent PTPS. Identifying modifiable clinical risk factors (procedure, physical and mental health, preoperative pain in the surgical area and another regions) seems to the most pragmatic approach for prevention for now. Effective acute pain management adopting a multimodal approach can result in a decreased incidence of PTPS. Interventional techniques such as paraverterbral blocks, intercostal blocks, and erector spinae blocks show some promise as well. Future research should be focused on minimally invasive surgeries and also the effect of ERAS protocols, including early mobilization, nutrition, and early removal of drains, on the development of PTPS.
Indexed as
Identifiers
32876936What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.