Evidence map›Paper›PMID 32876910›Full record

ArticleBreast cancer research and treatment2020

Risk factors for inflammatory and non-inflammatory breast cancer in North Africa.

Catherine Schairer, Ahmed Hablas, Ibrahim AbdelBar Seif Eldein, Rabab Gaafar, Henda Rais, Amel Mezlini, Farhat Ben Ayed, Wided Ben Ayoub, Abdellatif Benider, Ali Tahri and 12 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Global Aspects of the Cancer Epidemiology Education in Special Populations (CEESP) Program.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021
    Article
  5. Developing and Maintaining a Global Research Training Infrastructure for Cancer Education.Journal of cancer education : the official journal of the American Association for Cancer Education · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 11 institutions in 3 countries.

Catherine SchairerDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Ahmed HablasGharbiah Cancer Society, Tanta, Egypt.
Ibrahim AbdelBar Seif EldeinGharbiah Cancer Society, Tanta, Egypt.
Rabab GaafarNational Cancer Institute, Cairo, Egypt.
Henda RaisInstitute Salah Azaiz, Tunis, Tunisia.
Amel MezliniInstitute Salah Azaiz, Tunis, Tunisia.
Farhat Ben AyedAssociation for the Fight Against Cancer, Tunis, Tunisia.
Wided Ben AyoubInstitute Salah Azaiz, Tunis, Tunisia.
Abdellatif BeniderIbn Rochd University Hospital, Casablanca, Morocco.
Ali TahriClinique Spécialisée Menara, Marrakech, Morocco.
Mouna KhouchaniMohammed VI University Hospital, Marrakech, Morocco.
Dalia AboulazmNational Cancer Institute, Cairo, Egypt.
Mehdi KarkouriIbn Rochd University Hospital, Casablanca, Morocco.
Saad EissaNational Cancer Institute, Cairo, Egypt.
Ahmed El BastawisyNational Cancer Institute, Cairo, Egypt.
Maha YehiaNational Cancer Institute, Cairo, Egypt.
Shahinaz M GadallaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Sandra M SwainGeorgetown University Lombardi Comprehensive Cancer Center, Washington, DC, USA.
Sofia D MerajverUniversity of Michigan, Ann Arbor, MI, USA.
Linda Morris BrownRTI International, Rockville, MD, USA.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. pfeiffer@mail.nih.gov.ORCID http://orcid.org/0000-0001-7791-2698
Amr S SolimanMedical School of the City University of New York, New York, USA.
Institut Salah-Azaïz · TNCentre Hospitalier Universitaire Ibn Rochd · MANational Institutes of Health · USAssociation Tunisienne Contre le Cancer · TNCentre Hospitalier Universitaire Mohammed VI · MACity University of New York · USGeorgetown University · USPfeiffer University · USRTI International · USSup de Co Marrakech · MAUniversity of Michigan · US

Funding

Cancer Epidemiology Education in Special Populations Program-15R25CA112383 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Amr Soliman · 2006 to 2026
$6.1M
Intramural NIH HHS Z99 CA999999NCI NIH HHS R25 CA112383NIH HHS Grant R25 CA112383
6 · The paper itself

Abstract

purposeStudies of the etiology of inflammatory breast cancer (IBC), a rare but aggressive breast cancer, have been hampered by limited risk factor information. We extend previous studies by evaluating a broader range of risk factors.

methodsBetween 2009 and 2015, we conducted a case-control study of IBC at six centers in Egypt, Tunisia, and Morocco; enrolled were 267 IBC cases and for comparison 274 non-IBC cases and 275 controls, both matched on age and geographic area to the IBC cases. We administered questionnaires and collected anthropometric measurements for all study subjects. We used multiple imputation methods to account for missing values and calculated odds ratios (ORs) and 95% confidence intervals (CIs) using polytomous logistic regression comparing each of the two case groups to the controls, with statistical tests for the difference between the coefficients for the two case groups.

resultsAfter multivariable adjustment, a livebirth within the previous 2 years (OR 4.6; 95% CI 1.8 to 11.7) and diabetes (OR 1.8; 95% CI 1.1 to 3.0) were associated with increased risk of IBC, but not non-IBC (OR 0.9; 95% CI 0.3 to 2.5 and OR 0.9; 95% CI 0.5 to 1.6 for livebirth and diabetes, respectively). A family history of breast cancer, inflammatory-like breast problems, breast trauma, and low socioeconomic status were associated with increased risk of both tumor types.

conclusionsWe identified novel risk factors for IBC and non-IBC, some of which preferentially increased risk of IBC compared to non-IBC. Upon confirmation, these findings could help illuminate the etiology and aid in prevention of this aggressive cancer.

Indexed as

Breast NeoplasmsInflammatory Breast NeoplasmsCase-Control StudiesEgyptFemaleHumansMoroccoRisk FactorsTunisiaEgyptInflammatory breast cancerMoroccoRisk factorTunisia

Identifiers

PMID32876910
PMCPMC10440960
OpenAlexW3082949026

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.