Evidence map›Paper›PMID 32876860›Full record

ReviewChinese journal of integrative medicine2022

Roles of Gut Microbiota in Pathogenesis of Alzheimer's Disease and Therapeutic Effects of Chinese Medicine.

Ying-Xin Sun, Xi-Juan Jiang, Bin Lu, Qing Gao, Ye-Fei Chen, Dan-Bin Wu, Wen-Yun Zeng, Lin Yang, Hu-Hu Li, Bin Yu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Chinese journal of integrative medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ying-Xin SunSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xi-Juan JiangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Bin LuSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Qing GaoSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Ye-Fei ChenSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Dan-Bin WuSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wen-Yun ZengSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Lin YangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Hu-Hu LiSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Bin YuSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. Yubin_771115@hotmail.com.
Tianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.

Indexed as

Alzheimer DiseaseGastrointestinal MicrobiomeNeurodegenerative DiseasesBrainHumansHypothalamo-Hypophyseal SystemMedicine, Chinese TraditionalPituitary-Adrenal SystemAlzheimer’s diseaseChinese medicinegut microbiotapathogenesis

Identifiers

PMID32876860
OpenAlexW3082895243

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.