Evidence map›Paper›PMID 32876748›Full record

ArticleClinical oral investigations2020

A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2.

Maximilian J Gottsauner, Ioannis Michaelides, Barbara Schmidt, Konstantin J Scholz, Wolfgang Buchalla, Matthias Widbiller, Florian Hitzenbichler, Tobias Ettl, Torsten E Reichert, Christopher Bohr and 2 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04723446 (Efficacy of Three Antimicrobial Mouthwashes in Reducing SARS-CoV-2 Viral Load in the Saliva of Patients Diagnosed With COVID-19), which is not on this map. Cited by 57 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 6 pooled it
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04723446 nacompletednot on this mapstarted 2021, after this paper: background citation

Efficacy of Three Antimicrobial Mouthwashes in Reducing SARS-CoV-2 Viral Load in the Saliva of Patients Diagnosed With COVID-19: A Pilot Study

TypeinterventionalSponsorQueen Mary University of LondonRan2021 to 2021Enrolled54ConditionsCovid19, CoronavirusArmsCorsodyl® Alcohol free -0.2 % Chlorhexidine digluconate, Colgate Peroxyl® -1.5% Hydrogen peroxide, Oral-B® Gum & Enamel Care -Cetylpyridinium chloride, No rinsing
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 6 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Maximilian J GottsaunerDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Ioannis MichaelidesDepartment of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.
Barbara SchmidtInstitute of Clinical Microbiology and Hygiene, University Hospital Regensburg, Regensburg, Germany.
Konstantin J ScholzDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Wolfgang BuchallaDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Matthias WidbillerDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Florian HitzenbichlerDepartment of Infection Prevention and Infectious Diseases, University Hospital Regensburg, Regensburg, Germany.
Tobias EttlDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Torsten E ReichertDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Christopher BohrDepartment of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.
Veronika VielsmeierDepartment of Otorhinolaryngology, University Hospital Regensburg, Regensburg, Germany.
Fabian CieplikDepartment of Conservative Dentistry and Periodontology, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. fabian.cieplik@ukr.de.ORCID http://orcid.org/0000-0002-1750-7380
University Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate the effects of a 1% hydrogen peroxide mouthrinse on reducing the intraoral SARS-CoV-2 load.

methodsTwelve out of 98 initially screened hospitalized SARS-CoV-2-positive patients were included in this study. Intraoral viral load was determined by RT-PCR at baseline, whereupon patients had to gargle mouth and throat with 20 mL of 1% hydrogen peroxide for 30 s. After 30 min, a second examination of intraoral viral load was performed by RT-PCR. Furthermore, virus culture was performed for specimens exhibiting viral load of at least 10

resultsTen out of the 12 initially included SARS-CoV-2-positive patients completed the study. The hydrogen peroxide mouthrinse led to no significant reduction of intraoral viral load. Replicating virus could only be determined from one baseline specimen.

conclusionA 1% hydrogen peroxide mouthrinse does not reduce the intraoral viral load in SARS-CoV-2-positive subjects. However, virus culture did not yield any indication on the effects of the mouthrinse on the infectivity of the detected RNA copies. CLINICAL RELEVANCE: The recommendation of a preprocedural mouthrinse with hydrogen peroxide before intraoral procedures is questionable and thus should not be supported any longer, but strict infection prevention regimens are of paramount importance.

trial registrationGerman Clinical Trials Register (ref. DRKS00022484).

Indexed as

BetacoronavirusCoronavirus InfectionsPandemicsPneumonia, ViralAdultAgedAged, 80 and overCOVID-19FemaleHumansHydrogen PeroxideMaleMiddle AgedMouthwashesPilot ProjectsProspective StudiesHydrogen PeroxideMouthwashesCOVID-19GargleHydrogen peroxideIntraoralMouthrinseSARS-CoV-2Viral load

Identifiers

PMID32876748
PMCPMC7464055
OpenAlexW3082667024

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.