Evidence map›Paper›PMID 32876704›Full record

ArticleNeuroradiology2021

Corticospinal tract involvement in spinocerebellar ataxia type 3: a diffusion tensor imaging study.

Bruno Shigueo Yonekura Inada, Thiago Junqueira Ribeiro Rezende, Fernando Vieira Pereira, Lucas Ávila Lessa Garcia, Antônio José da Rocha, Pedro Braga Neto, Orlando Graziani Povoas Barsottini, Marcondes Cavalcante França, José Luiz Pedroso

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In one paragraph

Article in Neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  6. Observational
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  10. Impaired Oligodendrocyte Maturation Is an Early Feature in SCA3 Disease Pathogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Bruno Shigueo Yonekura InadaDivision of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. brunosy.inada@gmail.com.ORCID http://orcid.org/0000-0002-3000-6687
Thiago Junqueira Ribeiro RezendeDepartment of Neurology, State University of Campinas (UNICAMP), São Paulo, Brazil.
Fernando Vieira PereiraDivision of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Lucas Ávila Lessa GarciaDepartment of Neuroradiology, University of São Paulo (USP), São Paulo, Brazil.
Antônio José da RochaDepartment of Neuroradiology, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Pedro Braga NetoDepartment of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil.
Orlando Graziani Povoas BarsottiniDivision of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Marcondes Cavalcante FrançaDepartment of Neurology, State University of Campinas (UNICAMP), São Paulo, Brazil.
José Luiz PedrosoDivision of General Neurology and Ataxia Unit, Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Universidade Federal de São Paulo · BRUniversidade Estadual de Campinas (UNICAMP) · BRBeneficência Portuguesa de São Paulo · BRFaculdade de Ciências Médicas da Santa Casa de São Paulo · BRUniversidade de São Paulo · BRUniversidade Estadual do Ceará · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to evaluate the integrity of the corticospinal tracts (CST) in patients with SCA3 and age- and gender-matched healthy control subjects using diffusion tensor imaging (DTI). We also looked at the clinical correlates of such diffusivity abnormalities.

methodsWe assessed 2 cohorts from different Brazilian centers: cohort 1 (n = 29) scanned in a 1.5 T magnet and cohort 2 (n = 91) scanned in a 3.0 T magnet. We used Pearson's coefficients to assess the correlation of CST DTI parameters and ataxia severity (expressed by SARA scores).

resultsTwo different results were obtained. Cohort 1 showed no significant between-group differences in DTI parameters. Cohort 2 showed significant between-group differences in the FA values in the bilateral precentral gyri (p < 0.001), bilateral superior corona radiata (p < 0.001), bilateral posterior limb of the internal capsule (p < 0.001), bilateral cerebral peduncle (p < 0.001), and bilateral basis pontis (p < 0.001). There was moderate correlation between CST diffusivity parameters and SARA scores in cohort 2 (Pearson correlation coefficient: 0.40-0.59).

conclusionDTI particularly at 3 T is able to uncover and quantify CST damage in SCA3. Moreover, CST microstructural damage may contribute with ataxia severity in the disease.

Indexed as

Machado-Joseph DiseasePyramidal TractsWhite MatterDiffusion Tensor ImagingHumansInternal CapsuleCerebellar ataxiaCorticospinal tractDiffusion tensor imagingMachado-Joseph diseaseRetrograde degenerationSpinocerebellar ataxia type 3

Identifiers

PMID32876704
OpenAlexW3082230404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.