Evidence map›Paper›PMID 32876525›Full record

ArticleAdipocyte2020

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue.

Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Adipocyte, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Bin FengAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.ORCID 0000-0001-6258-2729
Yingguo ZhuAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Lijun YanAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Hui YanAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Xiaohua HuangAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Dandan JiangAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Zhen LiAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Lun HuaAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Yong ZhuoAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Zhengfeng FangAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Lianqiang CheAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Yan LinAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Shengyu XuAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Chao HuangCollege of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan, China.
Yuanfeng ZouCollege of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan, China.
Lixia LiCollege of Veterinary Medicine, Sichuan Agricultural University , Chengdu, Sichuan, China.ORCID 0000-0002-2772-264X
De WuAnimal Nutrition Institute, Sichuan Agricultural University , Chengdu, Sichuan, China.
Sichuan Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this study, 3T3-L1 adipocytes, DIO mice and lean mice were treated with UA or vehicle. Gene expression of inflammatory factors, chemokines and immune markers in adipocytes and adipose tissue, cytokines in cell culture medium and serum, and inflammation regulatory pathways in adipocytes were detected. Results showed that UA increased the expression of interleukins and chemokines, but not TNFα, in both adipocytes and adipose tissue. IL6 and MCP1 levels in the cell culture medium and mouse serum were induced by UA treatment. Cd14 expression level and number of CD14+ monocytes were higher in UA treated adipose tissue than those in the control group. Glucose tolerance test was impaired by UA treatment in DIO mice. Mechanistically, UA induced the expression of Tlr4 and the phosphorylation levels of ERK and NFκB in adipocytes. In conclusion, our study indicated that short-term UA administration could induce CD14+ monocytes infiltration by increasing the production of interleukins and chemokines in mouse adipose tissue, which might further impair glucose tolerance test.

Indexed as

3T3-L1 CellsAdipocytesAdipose TissueAnimalsBiomarkersChemokinesCytokinesFemaleGene Expression RegulationInflammation MediatorsInterleukin-6LipogenesisMaleMiceMonocytesPhosphorylationBiomarkersChemokinesCytokinesInflammation MediatorsInterleukin-6TriterpenesUrsolic AcidadipocytechemokineIL6MCP1monocyteTLR4Ursolic acid

Identifiers

PMID32876525
PMCPMC7714451
OpenAlexW3082142310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.