ArticleAnaesthesiology intensive therapy2020
Negative results for ketamine use in severe acute bronchospasm: a randomised controlled trial.
Article in Anaesthesiology intensive therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Use of ketamine in patients with refractory severe asthma exacerbations: systematic review of prospective studies.European journal of clinical pharmacology · 2022Pooled it
- Ketamine for Severe Asthma Exacerbation.Critical care explorations · 2026Observational
- Open and Closed Triple Inhaler Therapy in Patients with Uncontrolled Asthma.Advances in respiratory medicine · 2023Review
- [Ketamine as a treatment of bronchospasm due to an anaphylaxis. A case report].Revista medica del Instituto Mexicano del Seguro Social · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKetamine has bronchodilation properties. The aim of the single-centre, evaluator-blinded, randomised clinical trial study was to evaluate whether continuous infusion of ketamine is associated with improvement in respiratory mechanics correlated with bronchospasm relief, as compared with continuous infusion of fentanyl.
methodsAdult patients submitted to invasive mechanical ventilation were included if they had an acute severe bronchospasm, due to status asthmaticus or COPD exacerbation. They were randomised to ketamine or a standard IV analgesia with fentanyl, both in bolus and continuous infusion. Measurements of respiratory mechanics (airway resistance - R
resultsKetamine use was not associated with greater reduction in R
conclusionsIn this study, ketamine use was not associated with improvement in ventilatory variables associated with bronchospasm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.