ArticleeLife2020
Ultra-high-field imaging reveals increased whole brain connectivity underpins cognitive strategies that attenuate pain.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Human lesions and animal studies link the claustrum to perception, salience, sleep and pain.Brain : a journal of neurology · 2022Pooled it
- Article
- Brain connectivity in individuals with migraine resets during the headache phase: a whole-brain connectivity study.Brain communications · 2025Article
- Resting-state fNIRS reveals changes in prefrontal cortex functional connectivity during TENS in patients with chronic pain.Scientific reports · 2024Article
- Pain and the emotional brain: pain-related cortical processes are better reflected by affective evaluation than by cognitive evaluation.Scientific reports · 2023Article
- Review
- Article
- Balance recovery stepping responses during walking were not affected by a concurrent cognitive task among older adults.BMC geriatrics · 2022Article
- Investigation on how dynamic effective connectivity patterns encode the fluctuating pain intensity in chronic migraine.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
Abstract
We investigated how the attenuation of pain with cognitive interventions affects brain connectivity using neuroimaging and a whole brain novel analysis approach. While receiving tonic cold pain, 20 healthy participants performed three different pain attenuation strategies during simultaneous collection of functional imaging data at seven tesla. Participants were asked to rate their pain after each trial. We related the trial-by-trial variability of the attenuation performance to the trial-by-trial functional connectivity strength change of brain data. Across all conditions, we found that a higher performance of pain attenuation was predominantly associated with higher functional connectivity. Of note, we observed an association between low pain and high connectivity for regions that belong to brain regions long associated with pain processing, the insular and cingulate cortices. For one of the cognitive strategies (safe place), the performance of pain attenuation was explained by diffusion tensor imaging metrics of increased white matter integrity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.