ArticleeLife2020
Cryo-EM reveals species-specific components within the
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In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Review
- Deciphering the initiation pathway of CagT4SS assembly by in vitro reconstitution of subcomplexes.Nature communications · 2026Article
- Contributions of conserved and species-specific CagX (VirB9) domains to the assembly and function of theInfection and immunity · 2026Article
- Type IV Secretion System Drives Lipid Mixing.bioRxiv : the preprint server for biology · 2026Article
- Type IV secretion systems: from structures to mechanisms.The EMBO journal · 2025Review
- Article
- The structure of the Tad pilus alignment complex reveals a periplasmic conduit for pilus extension.Nature communications · 2025Article
- Species-specific components of theInfection and immunity · 2025Article
- Functional and intricate interaction network connectingmicroLife · 2025Article
- Special Issue: "Molecular Dynamics Simulations and Structural Analysis of Protein Domains".International journal of molecular sciences · 2024Article
- Cryo-EM structure of a conjugative type IV secretion system suggests a molecular switch regulating pilus biogenesis.The EMBO journal · 2024Article
- Fatty acids ofMicrobiology spectrum · 2024Article
- Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines.PLoS genetics · 2024Article
- Structural and functional diversity of type IV secretion systems.Nature reviews. Microbiology · 2024Review
- Recent Advances in Modeling Membrane β-Barrel Proteins Using Molecular Dynamics Simulations: From Their Lipid Environments to Their Assemblies.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Comparative Analysis of T4SS Molecular Architectures.Journal of microbiology and biotechnology · 2023Review
- Chimeric systems composed of swapped Tra subunits between distantly-related F plasmids reveal striking plasticity among type IV secretion machines.bioRxiv : the preprint server for biology · 2023Article
- A Proposal for a Consolidated Structural Model of the CagY Protein ofInternational journal of molecular sciences · 2023Article
- Role of the CagY antenna projection inInfection and immunity · 2023Article
- Assembly mechanism of a Tad secretion system secretin-pilotin complex.Nature communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Michael J Sheedlo *Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.ORCID 0000-0002-3185-1727
Jeong Min Chung *Life Sciences Institute, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-4285-8764
Neha SawhneyDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, United States.ORCID 0000-0002-4943-1018
Clarissa L DurieLife Sciences Institute, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-4027-4386
Timothy L CoverDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.ORCID 0000-0001-8503-002X
Melanie D OhiLife Sciences Institute, University of Michigan, Ann Arbor, United States.ORCID 0000-0003-1750-4793
D Borden LacyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, United States.ORCID 0000-0003-2273-8121
Funding
ZWITTERION SURFACTANT DDMAB FOR IMPROV STABIL OF PROTEINP41RR001209 · NCRR · STANFORD UNIVERSITY · PI GONZALEZ, ANA M · 1985 to 2011
$38.9MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9MRole of Iron and B-Catenin Activation in Gastric CarcinogenesisP01CA116087 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Kevin L Schey · 2009 to 2026
$27.5MTRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2012 to 2021
$14.7MTRAINING IN GASTROENTEROLOGYT32DK007673 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 1992 to 2026
$8.4MStructure-function analysis of H. pylori VacAR01AI039657 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI TIMOTHY L COVER · 1996 to 2026
$8.3MResource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2MType IV Protein Secretion in Helicobacter pyloriR01AI118932 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COVER, TIMOTHY L, OHI, MELANIE DIANE · 2016 to 2025
$6.7MSilicon Mechanics Compute ClusterS10OD020011 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKINIOTIS, GEORGIOS · 2015 to 2015
$490kStructural and functional studies of the Legionella pneumophila dot T4SSF32AI150027 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DURIE, CLARISSA LYNN · 2020 to 2021
$131k"Pathogenesis of Helicobacter pylori Infection"I01BX004447 · VA · VETERANS HEALTH ADMINISTRATION · PI TIMOTHY L COVER · 2019 to 2026
–BLRD VA I01 BX004447NCI NIH HHS P01 CA116087NCRR NIH HHS P41 RR001209NIAID NIH HHS F32 AI150027NIAID NIH HHS R01 AI039657NIAID NIH HHS R01 AI118932NIDDK NIH HHS P30 DK058404NIDDK NIH HHS T32 DK007673NIGMS NIH HHS P41 GM103310NIGMS NIH HHS P41 GM103311NIH HHS S10 OD020011
Abstract
The pathogenesis of
Indexed as
Bacterial ProteinsCryoelectron MicroscopyHelicobacter pyloriModels, MolecularProtein ConformationSpecies SpecificityType IV Secretion SystemsBacterial ProteinsType IV Secretion Systemsbacterial protein secretioncryo-electron microscopygastric cancerHelicobacter pyloriinfectious diseasemicrobiologymolecular machinetype iv secretion
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.