ArticleThe American journal of tropical medicine and hygiene2020
Case Report: Paralytic Ileus: A Potential Extrapulmonary Manifestation of Severe COVID-19.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Occam's razor or Hickam's dictum-COVID-19 is not a textbook aetiology of acute pancreatitis: A modified Naranjo Score appraisal.World journal of gastroenterology · 2023Pooled it
- A Systematic Review of Abdominal Imaging Findings in COVID-19 Patients.Visceral medicine · 2021Pooled it
- Peritonitis and paralytic ileus due to COVID-19 in a 29 weeks pregnant woman: a case report.BMC pregnancy and childbirth · 2026Article
- Visual analysis on ferroptosis and its cross-talk to coronavirus disease 2019 (COVID-19).Heliyon · 2024Article
- Atypical Complications during the Course of COVID-19: A Comprehensive Review.Medicina (Kaunas, Lithuania) · 2024Review
- Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19.Frontiers in pharmacology · 2024Article
- Article
- A Surgical Perspective of Gastrointestinal Manifestations and Complications of COVID-19 Infection.Gastroenterology clinics of North America · 2023Review
- Association between Red Blood Cell Distribution Width and Short-Term Mortality in Patients with Paralytic Intestinal Obstruction: Retrospective Data Analysis Based on the MIMIC-III Database.Emergency medicine international · 2023Article
- SARS-CoV-2 and gastrointestinal diseases.Frontiers in microbiology · 2023Review
- Acute pancreatitis and COVID-19: an integrative review of the literature.Revista do Colegio Brasileiro de Cirurgioes · 2023Review
- GASTROINTESTINAL COMPLICATIONS OF CORONAVIRUS DISEASE (COVID-19).Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2022Review
- Review of COVID-19, part 1: Abdominal manifestations in adults and multisystem inflammatory syndrome in children.Clinical imaging · 2021Review
- Acute hemorrhagic necrotizing pancreatitis in patient with COVID-19: a case report and review of literature.Journal of surgical case reports · 2021Article
- Acute mesenteric ischemia and small bowel imaging findings in COVID-19: A comprehensive review of the literature.World journal of gastrointestinal surgery · 2021Article
- Acute pancreatitis and COVID-19: A literature review.World journal of gastrointestinal surgery · 2021Article
- Acute abdomen in a 54-year-old COVID-19 patient: a case teport.Journal of surgical case reports · 2021Article
- Colonic Ileus, Distension, and Ischemia Due to COVID-19-Related Colitis: A Case Report and Literature Review.Cureus · 2021Article
- SARS-CoV-2-associated gastrointestinal and liver diseases: what is known and what is needed to explore.Egyptian liver journal · 2021Review
- A challenging case of COVID-19 infection presented with isolated acute abdominal pain: A case report and literature review.SAGE open medical case reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The COVID-19 pandemic has recently spread worldwide, presenting primarily in the form of pneumonia or other respiratory disease. In addition, gastrointestinal manifestations have increasingly been reported as one of the extrapulmonary features of the virus. We report two cases of SARS-CoV-2 infection complicated by paralytic ileus. The first patient was a 33-year-old man who was hospitalized with severe COVID-19 pneumonia requiring ventilator support and intensive care. He developed large bowel dilatation and perforation of the mid-transverse colon, and underwent laparotomy and colonic resection. Histopathology of the resected bowel specimen showed acute inflammation, necrosis, and hemorrhage, supporting a role for COVID-19-induced micro-thrombosis leading to perforation. The second patient was a 33-year-old man who had severe COVID-19 pneumonia, renal failure, and acute pancreatitis. His hospital course was complicated with paralytic ileus, and he improved with conservative management. Both cases were observed to have elevated liver transaminases, which is consistent with other studies. Several authors have postulated that the angiotensin-converting enzyme 2 receptors, the host receptors for COVID-19, that are present on enterocytes in both the small and large bowel might mediate viral entry and resultant inflammation. This is a potential mechanism of paralytic ileus in cases of severe COVID-19 infection. Recognizing paralytic ileus as a possible complication necessitates timely diagnosis and management.
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