Evidence map›Paper›PMID 32876010›Full record

Trial reportThe American journal of tropical medicine and hygiene2020

Primary Prophylaxis to Prevent Tuberculosis Infection in Prison Inmates: A Randomized, Double-Blind, Placebo-Controlled Trial.

Roberto Dias de Oliveira, Andrea da Silva Santos, Cassia Barbosa Reis, Alessandra de Cássia Leite, Flávia Patussi Correia Sacchi, Rafaele Carla Pivetta de Araujo, Paulo César Pereira Dos Santos, Valeria Cavalcanti Rolla, Leonardo Martinez, Jason Andrews and 1 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Serial Mass Screening for Tuberculosis Among Incarcerated Persons in Brazil.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Roberto Dias de Oliveira1State University of Mato Grosso do Sul, Dourados, Brazil.
Andrea da Silva Santos3Federal University of Grande Dourados, Dourados, Brazil.
Cassia Barbosa Reis1State University of Mato Grosso do Sul, Dourados, Brazil.
Alessandra de Cássia Leite2Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Flávia Patussi Correia Sacchi4Municipal Health Office, Dourados, Brazil.
Rafaele Carla Pivetta de Araujo3Federal University of Grande Dourados, Dourados, Brazil.
Paulo César Pereira Dos Santos3Federal University of Grande Dourados, Dourados, Brazil.
Valeria Cavalcanti Rolla5Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Leonardo Martinez6Stanford University, Stanford, California.
Jason Andrews6Stanford University, Stanford, California.
Julio Croda2Federal University of Mato Grosso do Sul, Campo Grande, Brazil.
Universidade Federal da Grande Dourados · BRFundação Oswaldo Cruz · BRStanford University · USUniversidade Estadual de Mato Grosso do Sul · BRUniversidade Federal de Mato Grosso do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many low- and middle-income countries, tuberculosis (TB) incidence in prisons is high, exposing incarcerated populations to an elevated risk of TB infection. We conducted a randomized, double-blind, placebo-controlled trial among HIV-negative male inmates of a high TB burden prison to determine whether isoniazid given twice weekly (900 mg) for 12 months prevents TB infection. The primary outcome was QuantiFERON-TB Gold in Plus (QFT) conversion to ≥ 0.35 international units per milliliter (IU/mL) at 6 months; secondary outcomes included alternative QFT thresholds (≥ 0.7, ≥ 2.0, and ≥ 4.0 IU/mL). In total, 467 participants were randomly assigned to intervention (

Indexed as

IsoniazidPrimary PreventionPrisonersAdultDouble-Blind MethodHumansIncidenceInterferon-gamma Release TestsLatent TuberculosisMycobacterium tuberculosisPrisonsTuberculin TestTuberculosisYoung AdultIsoniazid

Identifiers

PMID32876010
PMCPMC7543866
OpenAlexW3082085785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.