Evidence map›Paper›PMID 32875738›Full record

ArticleMolecular genetics & genomic medicine2020

Chromosome 2q33genetic polymorphisms in Tunisian endemic pemphigus foliaceus.

Olfa Abida, Emna Bahloul, Mariem Ben Jmaa, Khadija Sellami, Ferjani Zouidi, Raouia Fakhfakh, Nadia Mahfoudh, Hamida Turki, Hatem Masmoudi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics & genomic medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Olfa Abida"Autoimmunity, Cancer And Immunogenetics" research laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.ORCID 0000-0003-0208-145X
Emna BahloulDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Mariem Ben Jmaa"Autoimmunity, Cancer And Immunogenetics" research laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Khadija SellamiDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Ferjani Zouidi"Autoimmunity, Cancer And Immunogenetics" research laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.ORCID 0000-0002-2750-4802
Raouia Fakhfakh"Autoimmunity, Cancer And Immunogenetics" research laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.ORCID 0000-0001-5379-0622
Nadia MahfoudhImmunology Department, HediChaker Hospital, University of Sfax, Sfax, Tunisia.
Hamida TurkiDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Hatem Masmoudi"Autoimmunity, Cancer And Immunogenetics" research laboratory (LR18SP12), Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
University of Sfax · TN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeveral studies have suggested that polymorphisms within genes encoding T-lymphocyte immune regulating molecules: CD28, CTLA-4, and ICOS, may alter the signaling process and subsequently could be involved in susceptibility to a broad spectrum of autoimmune diseases.

methodsThis study aimed to replicate associations between common polymorphisms in the 2q33.2 cluster and susceptibility to pemphigus foliaceus (PF) in the Tunisian population. We investigated seven polymorphisms: rs3116496 and rs1879877 (CD28), rs231775, rs3087243, and (AT)

resultsWe confirmed the associations with CTLA4((AT)

conclusionOur results indicate that susceptibility to PF is located in the proximal and the distal 3' flanking region of the CTLA4/ICOS promoter. These findings may open avenues to the treatment of patients with biological drugs targeting CTLA4/ICOS molecules, in a personalized manner to achieve more effective treatment.

Indexed as

Polymorphism, Single NucleotideCD28 AntigensChromosomes, Human, Pair 2CTLA-4 AntigenHumansInducible T-Cell Co-Stimulator ProteinPemphigusTunisiaCD28 AntigensCTLA-4 AntigenCTLA4 protein, humanICOS protein, humanInducible T-Cell Co-Stimulator Protein2q33 polymorphismsgenetic susceptibilitypemphigus foliaceusTunisia

Identifiers

PMID32875738
PMCPMC7667300
OpenAlexW3081814007

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.