Evidence map›Paper›PMID 32875732›Full record

ArticleAdvanced healthcare materials2020

Diffusion Limited Cryopreservation of Tissue with Radiofrequency Heated Metal Forms.

Zonghu Han, Anirudh Sharma, Zhe Gao, Timothy W Carlson, M Gerard O'Sullivan, Erik B Finger, John C Bischof

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Advanced Rewarming Technologies for Cryopreservation.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
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  18. Vitrification and Nanowarming of Kidneys.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Zonghu HanDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.ORCID 0000-0002-2318-8734
Anirudh SharmaDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
Zhe GaoDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
Timothy W CarlsonDepartment of Veterinary Population Medicine, Comparative Pathology Shared Resource, Masonic Cancer Center, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA.
M Gerard O'SullivanDepartment of Veterinary Population Medicine, Comparative Pathology Shared Resource, Masonic Cancer Center, University of Minnesota, 1988 Fitch Avenue, Saint Paul, MN, 55108, USA.
Erik B FingerDepartment of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, USA.
John C BischofDepartment of Mechanical Engineering, University of Minnesota, 111 Church St., Minneapolis, MN, 55455, USA.
University of Minnesota · US

Funding

Organ banking for transplant—kidney cryopreservation by vitrification and novel nanowarming technologyR01DK117425 · NIDDK · UNIVERSITY OF MINNESOTA · PI JOHN C BISCHOF, Erik Brian Finger · 2018 to 2026
$4.9M
Breakthrough Tissue and Organ Preservation and Transplantation Using Scaled-Up Nanowarming TechnologyR01HL135046 · NHLBI · UNIVERSITY OF MINNESOTA · PI BISCHOF, JOHN C, FINGER, ERIK BRIAN · 2017 to 2020
$2.6M
NHLBI NIH HHS R01 HL135046NIDDK NIH HHS R01 DK117425
6 · The paper itself

Abstract

Cryopreserved tissues are increasingly needed in biomedical applications. However, successful cryopreservation is generally only reported for thin tissues (≤1 mm). This work presents several innovations to reduce cryoprotectant (CPA) toxicity and improve tissue cryopreservation, including 1) improved tissue warming rates through radiofrequency metal form and field optimization and 2) an experimentally verified predictive model to optimize CPA loading and rewarming to reduce toxicity. CPA loading is studied by microcomputed tomography (µCT) imaging, rewarming by thermal measurements, and modeling, and viability is measured after loading and/or cryopreservation by alamarBlue and histology. Loading conditions for three common CPA cocktails (6, 8.4, and 9.3 m) are designed, and then fast cooling and metal forms rewarming (up to 2000 °C min

Indexed as

CryopreservationCryoprotective AgentsHot TemperatureRadio WavesX-Ray MicrotomographyCryoprotective Agents2 mm thick tissue systemsporcine aortastissue cryopreservation

Identifiers

PMID32875732
PMCPMC7879698
OpenAlexW3082530100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.