Evidence map›Paper›PMID 32875393›Full record

ArticleJournal of molecular histology2020

Localization of angiotensin-(1-7) and Mas receptor in the rat ovary throughout the estrous cycle.

Virginia M Pereira, Fernando M Reis, Geovanni D Cassali, Sergio H S Santos, Maira Casalechi, Robson A S Santos, Adelina M Reis

Abstract read
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In one paragraph

Article in Journal of molecular histology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Virginia M PereiraDepartment of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Fernando M ReisDepartment of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. fmreis@ufmg.br.ORCID http://orcid.org/0000-0002-9258-7472
Geovanni D CassaliDepartment of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Sergio H S SantosInstitute of Agricultural Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Maira CasalechiDepartment of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Robson A S SantosDepartment of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Adelina M ReisDepartment of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Juiz de Fora · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 311903/2017-7
6 · The paper itself

Abstract

We have previously demonstrated the presence of Angiotensin (Ang)-(1-7) in rat ovary homogenates and its stimulatory effect on estradiol and progesterone production. The present study was undertaken to identify the cellular localization of Ang-(1-7) and its receptor Mas in the rat ovary in the different phases of the estrous cycle. Ang-(1-7) and Mas were localized by immunohistochemistry and Mas mRNA expression was assessed by RT-PCR. Immunostaining for both Ang-(1-7) and Mas was found in all phases of the estrous cycle, particularly in the thecal and interstitial cells, as well as in regressing corpora lutea. However, granulosa cells were positive only in antral and preovulatory follicles at proestrus and estrus phases. This pattern contrasted with the distribution of the octapeptide Ang II, which was abundant in granulosa but not in theca cells. In addition, the expression of Mas mRNA was demonstrated in all estrous cycle phases. Angiotensin-converting enzyme activity did not vary between estrous cycle phases, whereas prolyl endopeptidase activity was significantly higher in diestrus and neutral endopeptidase activity was significantly higher in metestrus. These data provide the first evidence that new RAS components are dynamically expressed in the ovary across the rat estrous cycle. Further functional studies should clarify the role of Ang-(1-7) signaling through Mas receptor in the regulation of ovarian physiology.

Indexed as

Estrous CycleAngiotensin IAngiotensin IIAnimalsBiomarkersEnzyme ActivationFemaleGranulosa CellsImmunohistochemistryOvarian FollicleOvaryPeptide FragmentsPeptidyl-Dipeptidase AProto-Oncogene MasProto-Oncogene ProteinsRatsACE protein, humanAngiotensin Iangiotensin I (1-7)Angiotensin IIBiomarkersPeptide FragmentsPeptidyl-Dipeptidase AProto-Oncogene MasProto-Oncogene ProteinsReceptors, G-Protein-CoupledRNA, MessengerAngiotensinEstrous cycleMas receptorOvaryRenin-angiotensin system

Identifiers

PMID32875393
OpenAlexW3082573863

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.