Evidence map›Paper›PMID 32875361›Full record

ArticleInternational ophthalmology2021

Syphilitic retinitis presentations: punctate inner retinitis and posterior placoid chorioretinitis.

Eva X DeVience, Sidney A Schechet, Marcia Carney, Mona Kaleem, Stephen DeVience, Luke Chang, Michael Gerbo, David M Hinkle

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Article in International ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Persistent syphilitic ocular manifestations despite treatment: a case series.Journal of ophthalmic inflammation and infection · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eva X DeVienceUniversity of Maryland Baltimore Washington Medical Center, Baltimore, MD, USA. evadevience@gmail.com.ORCID http://orcid.org/0000-0002-1558-4075
Sidney A SchechetElman Retina Group, Baltimore, MD, USA.
Marcia CarneyEastern Virginia Medical School, Norfolk, VA, USA.
Mona KaleemWilmer Eye Institute, Bethesda, MD, USA.
Stephen DeVienceCase Western Reserve University, Cleveland, OH, USA.
Luke ChangDepartment of Ophthalmology Medical College of Georgia Augusta University, Augusta, GA, USA.
Michael GerboWest Virginia University Eye Institute, Morgantown, WV, USA.
David M HinkleWest Virginia University Eye Institute, Morgantown, WV, USA.

Funding

American Glaucoma Society 2019 MAPS Research Grant
6 · The paper itself

Abstract

purposeTo describe two distinct presentations of syphilitic fundus features in a series of patients with ocular syphilis.

methodsThis is a retrospective, interventional case series of 22 eyes from 16 serology confirmed cases. Clinical examination, fluorescein angiography, and optical coherence tomography were performed at presentation and following high-dose intravenous penicillin G.

resultsIn our cohort, the mean age was 47.6 years (range 24-59 years) and 14 patients were male (87.5%), 11 patients were positive for human immunodeficiency virus (68.8%), and 6 had bilateral involvement (37.5%). Mean best-corrected visual acuity improved from 0.99 ± 0.79 logarithm of the minimal angle of resolution (LogMAR) at the time of presentation to 0.29 ± 0.36 LogMAR on final visit (P < 0.01). Posterior segment examinations in eyes with retinitis showed two distinct types (1) discrete, placoid lesions in the macula consistent with acute syphilitic posterior placoid chorioretinitis or (2) punctate inner retinitis with corresponding fluorescein pooling in a segmental pattern. These findings rapidly resolved after antibiotic therapy.

conclusionIn the era of resurgence, ocular syphilis may present with two phenotypes of discrete retinal lesions. Recognition of the characteristic ocular features may help make the diagnosis and monitor treatment response.

Indexed as

ChorioretinitisEye Infections, BacterialRetinitisSyphilisAdultFemaleFluorescein AngiographyHumansMaleMiddle AgedRetrospective StudiesTomography, Optical CoherenceYoung AdultChorioretinitisInflammationRetinal vasculitisRetinitisSyphilisUveitis

Identifiers

PMID32875361

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.