Evidence map›Paper›PMID 32875357›Full record

ArticleArchives of toxicology2020

Whole-brain R1 predicts manganese exposure and biological effects in welders.

David A Edmondson, Chien-Lin Yeh, Sébastien Hélie, Ulrike Dydak

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Higher R2* in the Red Nucleus Is Associated With Lead Exposure in an Asymptomatic Welder Cohort.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  6. Emerging technologies and their impact on regulatory science.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  7. Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

David A EdmondsonSchool of Health Sciences, Purdue University, 550 Stadium Dr., Hampton Hall of Civil Engineering, West Lafayette, IN, 47907, USA.
Chien-Lin YehSchool of Health Sciences, Purdue University, 550 Stadium Dr., Hampton Hall of Civil Engineering, West Lafayette, IN, 47907, USA.
Sébastien HélieDepartment of Psychological Sciences, Purdue University, West Lafayette, IN, USA.
Ulrike DydakSchool of Health Sciences, Purdue University, 550 Stadium Dr., Hampton Hall of Civil Engineering, West Lafayette, IN, 47907, USA. udydak@purdue.edu.ORCID 0000-0003-1852-7110
Purdue University West Lafayette · USCincinnati Children's Hospital Medical Center · USUniversity of Indianapolis · US

Funding

Neuroimaging for Early Diagnosis of Manganese Toxicity in Humans and RodentsR01ES020529 · NIEHS · PURDUE UNIVERSITY · PI DYDAK, ULRIKE · 2011 to 2015
$2.0M
3T MRI Scanner dedicated to Life Sciences ResearchS10OD012336 · OD · PURDUE UNIVERSITY · PI DYDAK, ULRIKE · 2015 to 2015
$2.0M
Multimodal Neuroimaging Approaches to Modeling Manganese ToxicityF31ES028081 · NIEHS · PURDUE UNIVERSITY · PI EDMONDSON, ALEX DEVYN · 2017 to 2018
$89k
NIEHS NIH HHS F31 ES028081NIEHS NIH HHS R01 ES020529NIH HHS S10 OD012336
6 · The paper itself

Abstract

Manganese (Mn) is a neurotoxicant that, due to its paramagnetic property, also functions as a magnetic resonance imaging (MRI) T1 contrast agent. Previous studies in Mn toxicity have shown that Mn accumulates in the brain, which may lead to parkinsonian symptoms. In this article, we trained support vector machines (SVM) using whole-brain R1 (R1 = 1/T1) maps from 57 welders and 32 controls to classify subjects based on their air Mn concentration ([Mn]

Indexed as

Occupational ExposureAdultAge FactorsAir Pollutants, OccupationalBrainBrain Chemistrygamma-Aminobutyric AcidHumansMagnetic Resonance ImagingMaleManganeseManganese PoisoningMetal WorkersMiddle AgedModels, BiologicalMovement DisordersAir Pollutants, Occupationalgamma-Aminobutyric AcidManganeseGABAMachine learningMagnetic resonance imagingManganeseNeuroimagingOccupational exposureR1Welding

Identifiers

PMID32875357
PMCPMC7581414
OpenAlexW3082063410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.