Evidence map›Paper›PMID 32875355›Full record

ArticleCellular and molecular life sciences : CMLS2021

Cellular prion protein dysfunction in a prototypical inherited metabolic myopathy.

Fatima-Zohra Boufroura, Céline Tomkiewicz-Raulet, Virginie Poindessous, Johan Castille, Jean-Luc Vilotte, Jean Bastin, Sophie Mouillet-Richard, Fatima Djouadi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. PrPJournal of cachexia, sarcopenia and muscle · 2025
    Article
  2. Review
  3. Excess PrPNature communications · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fatima-Zohra BoufrouraCentre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 15, rue de L'Ecole de Médecine, 75006, Paris, France.
Céline Tomkiewicz-RauletCentre Universitaire des Saints Pères, INSERM U1124, Sorbonne Université, Université de Paris, 75006, Paris, France.
Virginie PoindessousCentre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 15, rue de L'Ecole de Médecine, 75006, Paris, France.
Johan CastilleUniversité Paris-Saclay, INRAE AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, 78350, Jouy-en-Josas, France.
Jean-Luc VilotteUniversité Paris-Saclay, INRAE AgroParisTech, UMR1313 Génétique Animale et Biologie Intégrative, 78350, Jouy-en-Josas, France.
Jean BastinCentre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 15, rue de L'Ecole de Médecine, 75006, Paris, France.
Sophie Mouillet-Richard *Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 15, rue de L'Ecole de Médecine, 75006, Paris, France. sophie.mouillet-richard@parisdescartes.fr.
Fatima Djouadi *Centre de Recherche des Cordeliers, INSERM U1138, Sorbonne Université, Université de Paris, 15, rue de L'Ecole de Médecine, 75006, Paris, France. fatima.djouadi@inserm.fr.ORCID http://orcid.org/0000-0003-0350-0935
Inserm · FRAgroParisTech · FR

Funding

AFM-Téléthon Grant 2016-2017 #19607
6 · The paper itself

Abstract

Inherited fatty acid oxidation diseases in their mild forms often present as metabolic myopathies. Carnitine Palmitoyl Transferase 2 (CPT2) deficiency, one such prototypical disorder is associated with compromised myotube differentiation. Here, we show that CPT2-deficient myotubes exhibit defects in focal adhesions and redox balance, exemplified by increased SOD2 expression. We document unprecedented alterations in the cellular prion protein PrP

Indexed as

AnimalsCarnitine O-PalmitoyltransferaseCells, CulturedFocal AdhesionsHumansMiceMice, KnockoutMuscle Fibers, SkeletalMuscular DiseasesMyogenic Regulatory Factor 5Oxidation-ReductionPrion DiseasesPrion ProteinsRNA InterferenceSuperoxide DismutaseSuperoxide Dismutase 2Carnitine O-PalmitoyltransferaseMyogenic Regulatory Factor 5Prion ProteinsSuperoxide DismutaseSuperoxide Dismutase 2Cellular prion proteinFocal adhesionsInherited fatty acid oxidation disordersInherited metabolic myopathyMuscle differentiationRedox balance

Identifiers

PMID32875355
PMCPMC11073170
OpenAlexW3081813554

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.