ArticleBrain : a journal of neurology2020
Impairments of auditory scene analysis in posterior cortical atrophy.
Article in Brain : a journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 29 citations in OpenAlex.
- Non-verbal dichotic listening: A new cognitive hearing test for dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Musicality is Preserved in Neurodegeneration.The Yale journal of biology and medicine · 2026Review
- Article
- Hearing impairment and dementia: cause, catalyst or consequence?Journal of neurology · 2025Review
- Symptom-based staging for logopenic variant primary progressive aphasia.European journal of neurology · 2024Article
- Acute Aromatase Inhibition Impairs Neural and Behavioral Auditory Scene Analysis in Zebra Finches.eNeuro · 2024Article
- Behavioral Impairments and Increased Risk of Cortical Atrophy Risk Scores Among World Trade Center Responders.Journal of geriatric psychiatry and neurology · 2024Article
- Comprehension of acoustically degraded speech in Alzheimer's disease and primary progressive aphasia.Brain : a journal of neurology · 2023Article
- Diagnosis and Management of Posterior Cortical Atrophy.Current treatment options in neurology · 2023Review
- Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology.EBioMedicine · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Better conversations: a language and communication intervention for aphasia in posterior cortical atrophy.Neurocase · 2022Article
- An auditory-visual tradeoff in susceptibility to clutter.Scientific reports · 2021Article
- Processing of Degraded Speech in Brain Disorders.Brain sciences · 2021Review
- Hearing and dementia: from ears to brain.Brain : a journal of neurology · 2021Review
- Primary Progressive Aphasia: Toward a Pathophysiological Synthesis.Current neurology and neuroscience reports · 2021Review
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5 authors at 2 institutions in 1 country.
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Abstract
Although posterior cortical atrophy is often regarded as the canonical 'visual dementia', auditory symptoms may also be salient in this disorder. Patients often report particular difficulty hearing in busy environments; however, the core cognitive process-parsing of the auditory environment ('auditory scene analysis')-has been poorly characterized. In this cross-sectional study, we used customized perceptual tasks to assess two generic cognitive operations underpinning auditory scene analysis-sound source segregation and sound event grouping-in a cohort of 21 patients with posterior cortical atrophy, referenced to 15 healthy age-matched individuals and 21 patients with typical Alzheimer's disease. After adjusting for peripheral hearing function and performance on control tasks assessing perceptual and executive response demands, patients with posterior cortical atrophy performed significantly worse on both auditory scene analysis tasks relative to healthy controls and patients with typical Alzheimer's disease (all P < 0.05). Our findings provide further evidence of central auditory dysfunction in posterior cortical atrophy, with implications for our pathophysiological understanding of Alzheimer syndromes as well as clinical diagnosis and management.
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