Evidence map›Paper›PMID 32875248›Full record

ArticleACS omega2020

Dual Switch Mechanism of Erythropoietin as an Antiapoptotic and Pro-Angiogenic Determinant in the Retina.

Faith Pwaniyibo Samson, Weilue He, Srinivas R Sripathi, Ambrose Teru Patrick, Joshua Madu, Hyewon Chung, Megan C Frost, Donghyun Jee, Diana R Gutsaeva, Wan Jin Jahng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Inflammatory Biomarkers in Diabetic Macular Edema.Journal of clinical medicine · 2026
    Review
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  4. Review
  5. Article
  6. Article
  7. Article
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  9. Systemic and vitreous biomarkers - new insights in diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022
    Observational
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Faith Pwaniyibo SamsonDepartment of Petroleum Chemistry, American University of Nigeria, Yola 640101, Nigeria.
Weilue HeDepartment of Biomedical Engineering, Michigan Technological University, Houghton 49931, United States.
Srinivas R SripathiDepartment of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, United States.
Ambrose Teru PatrickDepartment of Petroleum Chemistry, American University of Nigeria, Yola 640101, Nigeria.
Joshua MaduDepartment of Petroleum Chemistry, American University of Nigeria, Yola 640101, Nigeria.
Hyewon ChungDepartment of Ophthalmology, School of Medicine, Konkuk University, Seoul 05030, Korea.
Megan C FrostDepartment of Biomedical Engineering, Michigan Technological University, Houghton 49931, United States.
Donghyun JeeDivision of Vitreous and Retina, Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon 16247, Korea.
Diana R GutsaevaDepartment of Ophthalmology, Augusta University, Augusta, Georgia 30912, United States.
Wan Jin JahngDepartment of Petroleum Chemistry, American University of Nigeria, Yola 640101, Nigeria.
American University of Nigeria · NGMichigan Technological University · USAugusta University · USJohns Hopkins University · USKonkuk University · KRThe Catholic University of Korea St. Vincent's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Constant or intense light degenerates the retina and retinal pigment epithelial cells. Light generates reactive oxygen species and nitric oxide leading to initial reactions of retinal degeneration. Apoptosis is the primary mechanism of abnormal death of photoreceptors, retinal ganglion cells, or retinal pigment epithelium (RPE) in degenerative retinal diseases, including diabetic retinopathy and age-related macular degeneration. The current study evaluated the function of erythropoietin (EPO) on angiogenesis and apoptosis in the retina and RPE under oxidative stress. We determined the pro-angiogenic and antiapoptotic mechanism of EPO under stress conditions using a conditional EPO knockdown model using siRNA, EPO addition, proteomics, immunocytochemistry, and bioinformatic analysis. Our studies verified that EPO protected retinal cells from light-, hypoxia-, hyperoxia-, and hydrogen peroxide-induced apoptosis through caspase inhibition, whereas up-regulated angiogenic reactions through vascular endothelial growth factor (VEGF) and angiotensin pathway. We demonstrated that the EPO expression in the retina and subsequent serine/threonine/tyrosine kinase phosphorylations might be linked to oxidative stress response tightly to determining angiogenesis and apoptosis. Neuroprotective roles of EPO may involve the balance between antiapoptotic and pro-angiogenic signaling molecules, including BCL-xL, c-FOS, caspase-3, nitric oxide, angiotensin, and VEGF receptor. Our data indicate a new therapeutic application of EPO toward retinal degeneration based on the dual roles in apoptosis and angiogenesis at the molecular level under oxidative stress.

Identifiers

PMID32875248
PMCPMC7450639
OpenAlexW3048658171

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.