ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Sex differences in memory clinic patients with possible vascular cognitive impairment.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Association of Self-Reported Sleep Metrics With Imaging Markers of Small Vessel Disease and Cognition in Patients With TIA or Mild Stroke.Neurology · 2025Article
- Review
- No sex differences in the association between regional brain structure abnormalities and cognitive functioning in a geriatric memory clinic population.Aging brain · 2025Article
- Near-lifespan mesoscopic optical imaging of cerebrovascular function reveals age and sex differences in preclinical Alzheimer's disease model.Brain communications · 2025Article
- Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds.JAMA network open · 2024Article
- Non-hemorrhagic imaging markers of cerebral amyloid angiopathy in memory clinic patients.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Navigating the Intersection of Sex, Vascular Risk Factors, and Cognitive Decline.JACC. Advances · 2024Article
- Sex Differences in the Association Between Vascular Risk Factors and Cognitive Decline: A UK Biobank Study.JACC. Advances · 2024Article
- Cerebral white matter rarefaction has both neurodegenerative and vascular causes and may primarily be a distal axonopathy.Journal of neuropathology and experimental neurology · 2023Article
- Neuropsychiatric symptoms in patients with possible vascular cognitive impairment, does sex matter?Cerebral circulation - cognition and behavior · 2022Article
- Gastrodin and Vascular Dementia: Advances and Current Perspectives.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Revealing the Influences of Sex Hormones and Sex Differences in Atrial Fibrillation and Vascular Cognitive Impairment.International journal of molecular sciences · 2021Review
- Sex differences in memory clinic patients with possible vascular cognitive impairment.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
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Authors and funding
12 authors.
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Abstract
introductionWe aimed to establish sex differences in vascular brain damage of memory clinic patients with possible vascular cognitive impairment (VCI).
methodsA total of 860 memory clinic patients (aged 67.7 ± 8.5; 46% female) with cognitive complaints and vascular brain damage (ie, possible VCI) from the prospective TRACE-VCI (Utrecht-Amsterdam Clinical Features and Prognosis in Vascular Cognitive Impairment) cohort study with 2-year follow-up were included. Age-adjusted female-to-male differences were calculated with general linear models, for demographic variables, vascular risk factors, clinical diagnosis, cognitive performance, and brain magnetic resonance imaging markers.
resultsWe found no difference in age nor distribution of clinical diagnoses between females and males. Females performed worse on the MMSE (Mini-Mental State Examination) and CAMCOG (Cognitive and Self-Contained Part of the Cambridge Examination for Mental Disorders of the Elderly). Females had a larger white matter hyperintensity volume, while males more often showed (lacunar) infarcts. There was no difference in microbleed prevalence. Males had smaller normalized total brain and gray matter volumes. During follow-up, occurrence of cognitive decline and institutionalization was comparable, but mortality was higher in males. DISCUSSION: Our results suggest that susceptibility and underlying etiology of VCI might differ by sex. Males seem to have more large vessel brain damage compared to females that have more small vessel brain damage.
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