ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2020
Lower retinal capillary density in minimal cognitive impairment among older Latinx adults.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Diagnosing neurodegenerative disorders using retina as an external window: A systematic review of OCT-MRI correlations.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Association between retinal markers and cognition in older adults: a systematic review.BMJ open · 2022Pooled it
- Quantitative ophthalmic posterior segment optical coherence tomography angiography and neurologic conditions: a review.Frontiers in neurologyPooled it
- Associations between multimodal retinal measurements and cognitive functions in patients with cerebral small vessel disease.Frontiers in neuroscience · 2026Article
- Brain and retina in Alzheimer's disease: Pathological intersections and estimates from imaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Macular vessel density is associated with cognitive function in preclinical p.R544C NOTCH3 mutation carriers.Journal of the Chinese Medical Association : JCMA · 2025Article
- Retinal vessel density and cognitive function in healthy older adults.Experimental brain research · 2025Article
- Non-Hospitalized Long COVID Patients Exhibit Reduced Retinal Capillary Perfusion: A Prospective Cohort Study.Journal of imaging · 2025Article
- Lower Retinal Arteriolar Density Is Associated With Higher Cerebral Small Vessel Disease Burden: An Optical Coherence Tomography Angiography Study.Brain and behavior · 2025Article
- Insight into the Brain: Application of the Retinal Microvasculature as a Biomarker for Cerebrovascular Diseases through Optical Coherence Tomography Angiography.Current ophthalmology reports · 2024Article
- Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Vessel density mapping of small cerebral vessels on 3D high resolution black blood MRI.NeuroImage · 2024Article
- The correlation between intracranial atherosclerosis and white matter hyperintensities in cerebral small vessel disease: a high-resolution magnetic resonance imaging study.Frontiers in neurology · 2024Article
- Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Differences in macular vessel density in the superficial plexus across cognitive impairment: the NORFACE cohort.Scientific reports · 2022Article
- Differentiating Degenerative from Vascular Dementia with the Help of Optical Coherence Tomography Angiography Biomarkers.Healthcare (Basel, Switzerland) · 2022Review
- OCTA Derived Vessel Skeleton Density Versus Flux and Their Associations With Systemic Determinants of Health.Investigative ophthalmology & visual science · 2022Article
- OCT and OCT Angiography Offer New Insights and Opportunities in Schizophrenia Research and Treatment.Frontiers in digital health · 2022Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- Evaluation of Cerebral Blood Flow Measured by 3D PCASL as Biomarker of Vascular Cognitive Impairment and Dementia (VCID) in a Cohort of Elderly Latinx Subjects at Risk of Small Vessel Disease.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe investigated the hypothesis that retinal capillary perfusion is a biomarker of early cognitive decline and cerebrovascular perfusion associated with small vessel disease in a pilot data set of Latinx adults at high risk for vascular cognitive impairment and dementia.
methodsHigh-resolution optical coherence tomography angiography (OCTA) images were acquired from dilated eyes of Latinx subjects using a 3 × 3 mm
resultsThe mean (± SD) age of the subjects was 68 (± 6) years. For every 0.01-unit lower VSD, the risk of having a CDR-SOB >0 was 20% higher (95%CI = 5%-90%; DISCUSSION: Impaired retinal capillary perfusion is associated with cognitive impairment and abnormalities in cerebrovascular perfusion and function. OCTA-based retinal capillary assessment holds promise for identifying and quantifying retinal correlates of neurovascular abnormalities associated with vascular cognitive impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.