Evidence map›Paper›PMID 32874828›Full record

ReviewActa pharmaceutica Sinica. B2020

Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives.

Somayeh Mahdinloo, Seyed Hossein Kiaie, Ala Amiri, Salar Hemmati, Hadi Valizadeh, Parvin Zakeri-Milani

Open access · diamondAbstract readReview
In one paragraph

Review in Acta pharmaceutica Sinica. B, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Nanomedicines in the Treatment of Liver Fibrosis: A Review.International journal of nanomedicine · 2025
    Review
  6. Thio-ProTide strategy: A novel HActa pharmaceutica Sinica. B · 2024
    Article
  7. Review
  8. Prospective therapeutics for intestinal and hepatic fibrosis.Bioengineering & translational medicine · 2023
    Review
  9. Article
  10. Lipid carriers for mRNA delivery.Acta pharmaceutica Sinica. B · 2023
    Review
  11. Article
  12. Article
  13. Insights on drug and gene delivery systems in liver fibrosis.Asian journal of pharmaceutical sciences · 2023
    Review
  14. Article
  15. Review
  16. Review
  17. Acta pharmaceutica Sinica. B · 2022
    Article
  18. Metabolic Syndrome: A Warning Sign of Liver Fibrosis.Journal of obesity & metabolic syndrome · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Somayeh MahdinlooFaculty of Pharmacy, Tabriz University of Medical Science, Tabriz 5166616471, Iran.
Seyed Hossein KiaieFaculty of Pharmacy, Tabriz University of Medical Science, Tabriz 5166616471, Iran.
Ala AmiriFaculty of Basic Sciences, Islamic Azad University, Science and Research Branch, Tehran 1477893855, Iran.
Salar HemmatiDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
Hadi ValizadehDrug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
Parvin Zakeri-MilaniLiver and Gastrointestinal Diseases Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz 5166616471, Iran.
Tabriz University of Medical Sciences · IRIslamic Azad University, Science and Research Branch · IRKermanshah University of Medical Sciences · IRUniversity of Tabriz · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis results from chronic damages together with an accumulation of extracellular matrix, and no specific medical therapy is approved for that until now. Due to liver metabolic capacity for drugs, the fragility of drugs, and the presence of insurmountable physiological obstacles in the way of targeting, the development of efficient drug delivery systems for anti-fibrotics seems vital. We have explored articles with a different perspective on liver fibrosis over the two decades, then collected and summarized the information by providing corresponding

Indexed as

Drug deliveryGene therapyHepatic stellate cellHerbal anti-fibroticLipid nanoparticleLiver fibrosisViral and non-viral vector

Identifiers

PMID32874828
PMCPMC7451940
OpenAlexW3018285954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.