ArticleJournal of health & pollution2020
Assessment of Thyroid Function and Oxidative Stress State in Foundry Workers Exposed to Lead.
Article in Journal of health & pollution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- Heavy metal exposures and constipation among United States adults: A cross-sectional study.Medicine · 2026Article
- Recent Advances in the Treatment of Thyroid Pathologies with Selenium-Containing Compounds, Nanoparticles and Nanocomplexes Based on Selenium and Selenoproteins.Biological trace element research · 2026Review
- Heavy Metal Air Pollution: Human Health Effects and Nanomaterial Strategies for Monitoring and Remediation.Biological trace element research · 2026Review
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- Chronic Occupational Exposure to Chemical Mixtures Induces Genomic Instability in Paint Workers.Toxics · 2025Article
- SOD2 genetics regulating mitochondrial management of oxidative stress is tied to chemical sensitivity in Gulf war veterans.Scientific reports · 2025Article
- Association between toxic heavy metals and noncancerous thyroid disease: a scoping review.PeerJ · 2025Article
- Article
- Association Between Blood Lead Levels and Thyroid Function: An Updated Systematic Review and Meta-Analysis.Indian journal of clinical biochemistry : IJCB · 2023Review
- Article
- The protective role of nutritional antioxidants against oxidative stress in thyroid disorders.Frontiers in endocrinology · 2022Review
- Selected Essential and Toxic Chemical Elements in Hypothyroidism-A Literature Review (2001-2021).International journal of molecular sciences · 2021Review
- The Influence of Oxidative Stress on Thyroid Diseases.Antioxidants (Basel, Switzerland) · 2021Article
- Occupational exposure to potentially toxic elements in the foundry industry: an integrated environmental and biological monitoring.Environmental science and pollution research international · 2021Article
- Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.International journal of molecular sciences · 2021Review
- Hospital admissions due to endocrine diseases in Korean male firefighters.Annals of occupational and environmental medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExposure to lead (Pb) has been associated with endocrine, hematological, gastrointestinal, renal and neurological problems in humans. However, effects on the thyroid gland are controversial.
objectivesThe aim of the present study was to assess thyroid function in foundry workers occupationally exposed to Pb and the mechanism of oxidative-antioxidant imbalance.
methodsThyroid function parameters and markers of oxidative stress were examined in 59 adult males who had been occupationally exposed to Pb. The results were then compared to those of 28 male subjects who had no history of Pb exposure or thyroid abnormalities and served as a control group.
resultsMean blood lead levels (16.5±1.74 μg/dl) were significantly higher among the exposed workers compared to those of the control group (12.8±1.16 μg/dl, (p <0.001)). The exposed group had significantly increased free triiodothyronine (FT3), free thyroxine (FT4) and significantly decreased thyroid stimulating hormone (TSH) (1.77±0.44 μIU/ml), whereas the control group had a TSH level of 2.61±0.94 μIU/ml (p< 0.0001). A state of oxidative stress was indicated by the significant increase in mean levels of malondialdehyde (MDA) and significant decrease in glutathione (GSH) (p < 0.0001). There was a significant positive correlation (r=0.358, p <0.05) between blood lead levels (BLL) and duration of employment, while BLL showed a significant negative correlation with TSH (r =-0.486, p <0.001), and GSH (r =-0.336, p <0.05). Of the occupationally exposed workers, 32.76% had elevated thyroid hormones. The results showed a significant positive relationship between GSH and TSH (β coefficient=0.274, p < 0.05), MDA with FT3 (β coefficient=0.355, p < 0.05) and FT4 (β coefficient = 0.491, p < 0.0001) among exposed workers.
conclusionsWorkers exposed to Pb dust proved to be at risk for hyperthyroidism, which was found to have a significant role in oxidative-antioxidant imbalance present among workers with increasing duration of exposure. PARTICIPANT CONSENT: Obtained. ETHICS APPROVAL: This study was approved by the Ethical Committee of the National Research Centre in Egypt (NRC) under the registration number 15225. COMPETING INTERESTS: The authors declare no competing financial interests.
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