Evidence map›Paper›PMID 32874728›Full record

ArticleSurgical neurology international2020

Cauda equina syndrome caused by lumbar leptomeningeal metastases from lung adenocarcinoma mimicking a schwannoma.

Giovanni Federico Nicoletti, Giuseppe Emmanuele Umana, Francesca Graziano, Alessandro Calì, Marco Fricia, Salvatore Cicero, Gianluca Scalia

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Surgical neurology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Neoplastic nerve lesions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Review
  5. Article
  6. Article
  7. The post spinal surgery syndrome: A review.Journal of craniovertebral junction & spine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giovanni Federico NicolettiNeurosurgery Unit, Highly Specialized Hospital and of National Importance "Garibaldi," Piazza Santa Maria di Gesù 5, Catania, Italy.
Giuseppe Emmanuele UmanaDepartment of Neurosurgery, Cannizzaro Hospital, Via Messina 829, Catania, Italy.
Francesca GrazianoNeurosurgery Unit, Highly Specialized Hospital and of National Importance "Garibaldi," Piazza Santa Maria di Gesù 5, Catania, Italy.
Alessandro CalìNeurosurgery Unit, Highly Specialized Hospital and of National Importance "Garibaldi," Piazza Santa Maria di Gesù 5, Catania, Italy.
Marco FriciaDepartment of Neurosurgery, Cannizzaro Hospital, Via Messina 829, Catania, Italy.
Salvatore CiceroDepartment of Neurosurgery, Cannizzaro Hospital, Via Messina 829, Catania, Italy.
Gianluca ScaliaNeurosurgery Unit, Highly Specialized Hospital and of National Importance "Garibaldi," Piazza Santa Maria di Gesù 5, Catania, Italy.
Ospedale Garibaldi · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCauda equina syndromes (CESs) due to leptomeningeal metastases from primitive lung tumors are rare. Despite recent advancements in neuro-oncology and molecular biology, the prognosis for these patients remains poor. Here, we present a case in which a patient developed lumbar leptomeningeal metastases from lung carcinoma that contributed to a CES and reviewed the appropriate literature. CASE DESCRIPTION: A 55-year-old female presented with the left lower extremity sciatica/weakness. Two years ago, a then 53-year-old female had received Gamma Knife stereotactic radiosurgery (SRS) for a cerebellopontine angle schwannoma. Recently, she underwent resection of lung carcinoma and SRS for a right hemispheric cerebellar metastasis. Now at age 55, she presented with the left lower extremity sciatica/weakness. When her new lumbar MR was interpreted as showing a L5 schwannoma, a L4-L5 laminectomy was performed at surgery, the authors encountered multifocal leptomeningeal metastases densely infiltrating the cauda equina. Although only subtotal resection/decompression of tumor was feasible, she did well for the ensuing year. The histological diagnosis confirmed the lesion to be a poorly differentiated lung adenocarcinoma.

conclusionPatients with a history of prior metastatic lung cancer may present with spinal leptomeningeal metastases resulting in a CES.

Indexed as

Cauda equinaLeptomeningealLung cancerMetastasesSchwannoma

Identifiers

PMID32874728
PMCPMC7451188
OpenAlexW3046338427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.