Evidence map›Paper›PMID 32874638›Full record

ArticleRoyal Society open science2020

Far-red pentamethine cyanine dyes as fluorescent probes for the detection of serum albumins.

D Aristova, G Volynets, S Chernii, M Losytskyy, A Balanda, Yu Slominskii, A Mokhir, S Yarmoluk, V Kovalska

Abstract read
In one paragraph

Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Mechanistic Insight into the Thermal "Blueing" of Cyanine Dyes.Journal of the American Chemical Society · 2024
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

D AristovaInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
G VolynetsInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
S CherniiInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
M LosytskyyInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
A BalandaInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
Yu SlominskiiInstitute of Organic Chemistry NASU, 5 Murmans'ka Street, 02094 Kyiv, Ukraine.
A MokhirOrganic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Nikolaus-Fiebiger-Strasse 10, 91058 Erlangen, Germany.
S YarmolukInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.
V KovalskaInstitute of Molecular Biology and Genetics NASU, 150 Zabolotnogo Street, 03143 Kyiv, Ukraine.ORCID 0000-0001-8305-9398

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benzothiazole based cyanine dyes with bridged groups in the pentamethine chain were studied as potential far-red fluorescent probes for protein detection. Spectral-luminescent properties were characterized for unbound dyes and in the presence of serum albumins (bovine (BSA), human (HSA), equine (ESA)), and globular proteins (β-lactoglobulin, ovalbumin). We have observed that the addition of albumins leads to a significant increase in dyes fluorescence intensity. However, the fluorescent response of dyes in the presence of other globular proteins was notably lower. The value of fluorescence quantum yield for dye bearing a sulfonate group complexed with HSA amounted to 42% compared with 0.2% for the free dye. The detection limit of HSA by this dye was greater than 0.004 mg ml

Indexed as

far-red fluorescent probesglobular proteinsmolecular dockingpentamethine cyanine dyesserum albumins

Identifiers

PMID32874638
PMCPMC7428273

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.