Evidence map›Paper›PMID 32874504›Full record

ReviewChemical science2020

Peptide and protein modified metal clusters for cancer diagnostics.

Dongdong Su, Liang Gao, Fuping Gao, Xiangchun Zhang, Xueyun Gao

Abstract readReview
In one paragraph

Review in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Dongdong SuDepartment of Chemistry and Chemical Engineering , Beijing University of Technology , Beijing 100124 , China . Email: gaoxy@ihep.ac.cn.ORCID 0000-0002-7463-4466
Liang GaoDepartment of Chemistry and Chemical Engineering , Beijing University of Technology , Beijing 100124 , China . Email: gaoxy@ihep.ac.cn.ORCID 0000-0002-9337-345X
Fuping GaoInstitute of High Energy Physics , Chinese Academy of Sciences , Beijing 100049 , China.ORCID 0000-0002-0287-9763
Xiangchun ZhangTea Research Institute , Chinese Academy of Agricultural Sciences , Hangzhou , 310008 , China.
Xueyun GaoDepartment of Chemistry and Chemical Engineering , Beijing University of Technology , Beijing 100124 , China . Email: gaoxy@ihep.ac.cn.ORCID 0000-0002-2267-9945

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The biomedical features of metal clusters have been explored in tumor diagnostic applications in recent years. Peptide or protein protected metal clusters with low toxicity, ultra-small size and good biocompatibility are ideal bioanalytical tools, and exhibit better cancer diagnostic properties that have been attractive to oncologists. This perspective provides a rigorous but succinct overview of cancer diagnosis as a working concept for metal clusters by reporting the latest significant advances in the applications of metal clusters in tumor-related bioanalysis and diagnosis. The materials design principles, bioanalytical mechanisms and biomedical applications of metal clusters are described, and then the potential challenges and prospects of metal clusters in cancer diagnosis are discussed. A perspective addressing the role of metal clusters in this field is required to understand their effects and functions, as well as for the scientific community to further advance the development of metal clusters for broader diagnostic applications.

Identifiers

PMID32874504
PMCPMC7444476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.