ArticleChemical science2020
Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability.
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Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
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Who cites it
17 citing papers in PubMed, 39 citations in OpenAlex.
- Cartilage targeting cationic peptide carriers display deep cartilage penetration and retention in a rabbit model of post-traumatic osteoarthritis.Osteoarthritis and cartilage · 2025Article
- Tackling Undruggable Targets with Designer Peptidomimetics and Synthetic Biologics.Chemical reviews · 2024Review
- Mirror-image ligand discovery enabled by single-shot fast-flow synthesis of D-proteins.Nature communications · 2024Article
- Design-rules for stapled peptides with in vivo activity and their application to Mdm2/X antagonists.Nature communications · 2024Article
- Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein.RSC chemical biology · 2023Article
- Design, synthesis and antitumor activity of Ascaphin-8 derived stapled peptides based on halogen-sulfhydryl click chemical reactions.RSC advances · 2023Article
- Synthesis and applications of mirror-image proteins.Nature reviews. Chemistry · 2023Review
- Lessons for Oral Bioavailability: How Conformationally Flexible Cyclic Peptides Enter and Cross Lipid Membranes.Journal of medicinal chemistry · 2023Article
- Learn from antibody-drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy.Experimental hematology & oncology · 2022Review
- Stapled peptides as scaffolds for developing radiotracers for intracellular targets: Preliminary evaluation of a radioiodinated MDM2-binding stapled peptide in the SJSA-1 osteosarcoma model.Bioorganic & medicinal chemistry letters · 2022Article
- Targeting intracellular protein-protein interactions with macrocyclic peptides.Trends in pharmacological sciences · 2022Review
- Whole-body PET tracking of a d-dodecapeptide and its radiotheranostic potential for PD-L1 overexpressing tumors.Acta pharmaceutica Sinica. B · 2022Article
- A Selective Inhibitor of Cardiac Troponin I Phosphorylation by Delta Protein Kinase C (δPKC) as a Treatment for Ischemia-Reperfusion Injury.Pharmaceuticals (Basel, Switzerland) · 2022Article
- His-Ala-Phe-Lys peptide fromFrontiers in microbiology · 2022Article
- Peptide-based inhibitors of protein-protein interactions: biophysical, structural and cellular consequences of introducing a constraint.Chemical science · 2021Review
- Strategies to expand peptide functionality through hybridisation with a small molecule component.RSC chemical biology · 2021Review
- Design, Synthesis, and Antitumor Activities Study of Stapled A4K14-Citropin 1.1 Peptides.Frontiers in chemistry · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 3 institutions in 4 countries.
Srinivasaraghavan KannanBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.ORCID 0000-0002-9539-5249
Pietro G A AronicaBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.
Simon Ngp53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Dawn Thean Gek Lianp53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Yuri Frosip53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Sharon Cheep53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Jiang Shiminp53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Tsz Ying YuenInstitute of Chemical & Engineering Science , Agency for Science, Technology and Research (ASTAR) , 8 Biomedical Grove, #07, Neuros Building , Singapore 138665.ORCID 0000-0001-7971-1726
Ahmad SadruddinMSD International , Translation Medicine Research Centre , 8 Biomedical Grove, #04-01/05 Neuros Building , Singapore , 138665 , Singapore . Email: anthony_partridge@merck.com.
Hung Yi Kristal KaanMSD International , Translation Medicine Research Centre , 8 Biomedical Grove, #04-01/05 Neuros Building , Singapore , 138665 , Singapore . Email: anthony_partridge@merck.com.
Arun ChandramohanMSD International , Translation Medicine Research Centre , 8 Biomedical Grove, #04-01/05 Neuros Building , Singapore , 138665 , Singapore . Email: anthony_partridge@merck.com.
Jin Huei WongBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.
Yaw Sing TanBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.
Zi Wei ChangSingapore Immunology Network (SIgN) , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #03-06, Immunos , Singapore 138648.ORCID 0000-0002-7461-9098
Fernando J Ferrer-Gagop53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Prakash ArumugamBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.
Yi HanMerck & Co., Inc. , Kenilworth , New Jersey , USA.
Shiying ChenMerck & Co., Inc. , Kenilworth , New Jersey , USA.
Laurent RéniaSingapore Immunology Network (SIgN) , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #03-06, Immunos , Singapore 138648.
Christopher J Brownp53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Charles W JohannesInstitute of Chemical & Engineering Science , Agency for Science, Technology and Research (ASTAR) , 8 Biomedical Grove, #07, Neuros Building , Singapore 138665.
Brian HenryMSD International , Translation Medicine Research Centre , 8 Biomedical Grove, #04-01/05 Neuros Building , Singapore , 138665 , Singapore . Email: anthony_partridge@merck.com.
David P Lanep53 Laboratory , Agency for Science, Technology and Research (ASTAR) , 8A Biomedical Grove, #06-04/05, Neuros/Immunos , Singapore 138648.
Tomi K SawyerMerck & Co., Inc. , Boston , Massachusetts , USA.
Chandra S VermaBioinformatics Institute , Agency for Science, Technology and Research (ASTAR) , 30 Biopolis Street, #07-01 Matrix , Singapore 138671 , Singapore . Email: raghavk@bii.a-star.edu.sg ; Email: chandra@bii.a-star.edu.sg ; ; Tel: +65 6478 8353 ; Tel: +65 6478 8273.ORCID 0000-0003-0733-9798
Anthony W PartridgeMSD International , Translation Medicine Research Centre , 8 Biomedical Grove, #04-01/05 Neuros Building , Singapore , 138665 , Singapore . Email: anthony_partridge@merck.com.ORCID 0000-0001-8568-2079
Agency for Science, Technology and Research · SGMSD K.K. (Japan) · JPMerck & Co., Inc., Rahway, NJ, USA (United States) · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein-protein interactions (PPIs). Indeed, the vast diversity of chemical space conferred through their primary, secondary and tertiary structures allows these molecules to be applied to targets that are typically deemed intractable
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.