Evidence map›Paper›PMID 32874501›Full record

ArticleChemical science2020

A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst.

Noboru Hayama, Yusuke Kobayashi, Eriko Sekimoto, Anna Miyazaki, Kiyofumi Inamoto, Tetsutaro Kimachi, Yoshiji Takemoto

Abstract read
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Noboru HayamaGraduate School of Pharmaceutical Sciences , Kyoto University , Yoshida, Sakyo-ku , Kyoto 606-8501 , Japan . Email: takemoto@pharm.kyoto-u.ac.jp.
Yusuke KobayashiGraduate School of Pharmaceutical Sciences , Kyoto University , Yoshida, Sakyo-ku , Kyoto 606-8501 , Japan . Email: takemoto@pharm.kyoto-u.ac.jp.ORCID 0000-0003-3074-7378
Eriko SekimotoSchool of Pharmacy and Pharmaceutical Sciences , Mukogawa Women's University , 11-68, 9-Bancho, Koshien , Nishinomiya , Hyogo 663-8179 , Japan.
Anna MiyazakiSchool of Pharmacy and Pharmaceutical Sciences , Mukogawa Women's University , 11-68, 9-Bancho, Koshien , Nishinomiya , Hyogo 663-8179 , Japan.
Kiyofumi InamotoSchool of Pharmacy and Pharmaceutical Sciences , Mukogawa Women's University , 11-68, 9-Bancho, Koshien , Nishinomiya , Hyogo 663-8179 , Japan.
Tetsutaro KimachiSchool of Pharmacy and Pharmaceutical Sciences , Mukogawa Women's University , 11-68, 9-Bancho, Koshien , Nishinomiya , Hyogo 663-8179 , Japan.
Yoshiji TakemotoGraduate School of Pharmaceutical Sciences , Kyoto University , Yoshida, Sakyo-ku , Kyoto 606-8501 , Japan . Email: takemoto@pharm.kyoto-u.ac.jp.ORCID 0000-0003-1375-3821

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported. Both enantiomers of the Michael adducts can be obtained in high enantioselectivity and good yield merely by changing the solvent. The origin of the chirality switch in the products was examined in each solvent

Identifiers

PMID32874501
PMCPMC7444369

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.