Evidence map›Paper›PMID 32874486›Full record

ArticleChemical science2019

Designing stable, hierarchical peptide fibers from block co-polypeptide sequences.

Mark M J van Rijt, Adriano Ciaffoni, Alessandro Ianiro, Mohammad-Amin Moradi, Aimee L Boyle, Alexander Kros, Heiner Friedrich, Nico A J M Sommerdijk, Joseph P Patterson

Abstract read
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In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mark M J van RijtLaboratory of Materials and Interface Chemistry , Centre for Multiscale Electron Microscopy , Department of Chemical Engineering and Chemistry , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands . Email: patters3@uci.edu ; Email: nico.sommerdijk@radboudumc.nl.ORCID 0000-0002-9134-7493
Adriano CiaffoniDepartment of Supramolecular & Biomaterials Chemistry , Leiden Institute of Chemistry , Leiden University , P. O. Box 9502, 2300 RA , Leiden , The Netherlands.
Alessandro IaniroInstitute for Complex Molecular Systems , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands.ORCID 0000-0003-4709-4350
Mohammad-Amin MoradiLaboratory of Materials and Interface Chemistry , Centre for Multiscale Electron Microscopy , Department of Chemical Engineering and Chemistry , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands . Email: patters3@uci.edu ; Email: nico.sommerdijk@radboudumc.nl.ORCID 0000-0003-3754-9200
Aimee L BoyleDepartment of Supramolecular & Biomaterials Chemistry , Leiden Institute of Chemistry , Leiden University , P. O. Box 9502, 2300 RA , Leiden , The Netherlands.ORCID 0000-0003-4176-6080
Alexander KrosDepartment of Supramolecular & Biomaterials Chemistry , Leiden Institute of Chemistry , Leiden University , P. O. Box 9502, 2300 RA , Leiden , The Netherlands.ORCID 0000-0002-3983-3048
Heiner FriedrichLaboratory of Materials and Interface Chemistry , Centre for Multiscale Electron Microscopy , Department of Chemical Engineering and Chemistry , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands . Email: patters3@uci.edu ; Email: nico.sommerdijk@radboudumc.nl.ORCID 0000-0003-4582-0064
Nico A J M SommerdijkLaboratory of Materials and Interface Chemistry , Centre for Multiscale Electron Microscopy , Department of Chemical Engineering and Chemistry , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands . Email: patters3@uci.edu ; Email: nico.sommerdijk@radboudumc.nl.ORCID 0000-0002-8956-195X
Joseph P PattersonLaboratory of Materials and Interface Chemistry , Centre for Multiscale Electron Microscopy , Department of Chemical Engineering and Chemistry , Eindhoven University of Technology , P. O. Box 513 , 5600 MB Eindhoven , The Netherlands . Email: patters3@uci.edu ; Email: nico.sommerdijk@radboudumc.nl.ORCID 0000-0002-1975-1854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural materials, such as collagen, can assemble with multiple levels of organization in solution. Achieving a similar degree of control over morphology, stability and hierarchical organization with equilibrium synthetic materials remains elusive. For the assembly of peptidic materials the process is controlled by a complex interplay between hydrophobic interactions, electrostatics and secondary structure formation. Consequently, fine tuning the thermodynamics and kinetics of assembly remains extremely challenging. Here, we synthesized a set of block co polypeptides with varying hydrophobicity and ability to form secondary structure. From this set we select a sequence with balanced interactions that results in the formation of high-aspect ratio thermodynamically favored nanotubes, stable between pH 2 and 12 and up to 80 °C. This stability permits their hierarchical assembly into bundled nanotube fibers by directing the pH and inducing complementary zwitterionic charge behavior. This block co-polypeptide design strategy, using defined sequences, provides a straightforward approach to creating complex hierarchical peptide-based assemblies with tunable interactions.

Identifiers

PMID32874486
PMCPMC7449534

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.