Evidence map›Paper›PMID 32874485›Full record

ArticleChemical science2019

Multi-functionalised graphene nanoflakes as tumour-targeting theranostic drug-delivery vehicles.

Jennifer Lamb, Eliane Fischer, Martin Rosillo-Lopez, Christoph G Salzmann, Jason P Holland

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 29 citations in OpenAlex.

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  11. Nanoscale Radiotheranostics for Cancer Treatment: From Bench to Bedside.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jennifer LambDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , CH-8057 , Zurich , Switzerland . Email: jason.holland@chem.uzh.ch ; http://www.hollandlab.org ; Tel: +41 44 63 53 990.
Eliane FischerDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , CH-8057 , Zurich , Switzerland . Email: jason.holland@chem.uzh.ch ; http://www.hollandlab.org ; Tel: +41 44 63 53 990.
Martin Rosillo-LopezDepartment of Chemistry , University College London , 20 Gordon Street , London WC1H 0AJ , UK.
Christoph G SalzmannDepartment of Chemistry , University College London , 20 Gordon Street , London WC1H 0AJ , UK.ORCID 0000-0002-0714-7342
Jason P HollandDepartment of Chemistry , University of Zurich , Winterthurerstrasse 190 , CH-8057 , Zurich , Switzerland . Email: jason.holland@chem.uzh.ch ; http://www.hollandlab.org ; Tel: +41 44 63 53 990.ORCID 0000-0002-0066-219X
University of Zurich · CHUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graphene nanoflakes (GNFs) consist of a graphene sheet approximately 30 nm in diameter with a pristine aromatic system and an edge terminated with carboxylic acid groups. Their high water solubility and relative ease of functionalisation using carboxylate chemistry means that GNFs are potential scaffolds for the synthesis of theranostic agents. In this work, GNFs were multi-functionalised with derivatives of (i) a peptide-based Glu-NH-C(O)-NH-Lys ligand that binds prostate-specific membrane antigen (PSMA), (ii) a potent anti-mitotic drug (

Identifiers

PMID32874485
PMCPMC7449665
OpenAlexW2967300801

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.