ArticleSaudi journal of biological sciences2020
Differential proteomics analysis of serum exosomein burn patients.
Article in Saudi journal of biological sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Burn-associated metabolic dysfunction: could extracellular vesicles play a role?Clinical science (London, England : 1979) · 2026Review
- Extracellular vesicles in burn injury: roles, mechanisms, and applications.Burns & trauma · 2025Review
- Exosomes in nanomedicine: a promising cell-free therapeutic intervention in burn wounds.Stem cell research & therapy · 2024Review
- Enhancing of cerebral Abeta clearance by modulation of ABC transporter expression: a review of experimental approaches.Frontiers in aging neuroscience · 2024Review
- Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives.International journal of biological sciences · 2023Review
- Article
- S100A9‑containing serum exosomes obtained from patients with burn injuries promote myocardial cell pyroptosis through NLRP3.Experimental and therapeutic medicine · 2022Article
- miR-351 promotes atherosclerosis in diabetes by inhibiting the ITGB3/PIK3R1/Akt pathway and induces endothelial cell injury and lipid accumulation.Molecular medicine (Cambridge, Mass.) · 2022Article
- Multimerin-1 and cancer: a review.Bioscience reports · 2022Review
- Platelet-Derived Exosomes and Atherothrombosis.Frontiers in cardiovascular medicine · 2022Review
- Kukoamine A ImprovesBioMed research international · 2022Article
- Alarming Cargo: The Role of Exosomes in Trauma-Induced Inflammation.Biomolecules · 2021Review
- S100A9-containing serum exosomes of burn injury patients promote permeability of pulmonary microvascular endothelial cells.Journal of biosciences · 2021Article
- Exosomes: Emerging Diagnostic and Therapeutic Targets in Cutaneous Diseases.International journal of molecular sciences · 2020Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exosome is an emerging concepts biomarkers due to their abnormal expression in various diseases. Research on exosome has already shifted from the laboratory to clinical application. This study uses bioinformatics technology to identify functional changes in proteins of serum exosomes from burn patients. A total of 231 quantifiable differentially-expressed proteins were screened out, 31 of them had statistically significant changes in expression levels. In the test group, expression of2 proteins had downregulated, whereas that of 29 proteins upregulated. Gene Ontology analysis demonstrates that differentially-expressed proteins were primarily identified in extracellular vesicles and platelet α granules, which can alter enzyme inhibitor activities, heparin-binding, coagulation, and lipid transport. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrates that ITGA2B and ITGB3 proteins, which were significantly upregulated in the burn group, were primarily involved in the PI3K/AKT signaling pathway. Western blotting confirmed that the expressions of ITGA2B and ITGB3 in burn patient tissue samples were higher than those in the control group; conversely, the expression of CD9 was lower than that in the control group. In burn patients, the upregulated proteins ITGA2B and ITGB3 of serum exosomes likely participate in injury detection and repair via PI3K/AKT signaling pathways.
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Registered trials
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