Evidence map›Paper›PMID 32874006›Full record

ArticleIndian journal of pharmacology

Co-abuse of alprazolam augments the hepato-renal toxic effects of methylphenidate.

Meenu Dutt, Ravinder Naik Dharavath, Tanzeer Kaur, Navpreet Kaur, Kanwaljit Chopra, Shweta Sharma

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Indian journal of pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meenu DuttForensic Toxicology Lab, Institute of Forensic Sciences and Criminology, Panjab University, Chandigarh, India.
Ravinder Naik DharavathPharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Tanzeer KaurDepartment of Biophysics, Panjab University, Chandigarh, India.
Navpreet KaurForensic Toxicology Lab, Institute of Forensic Sciences and Criminology, Panjab University, Chandigarh, India.
Kanwaljit ChopraPharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Shweta SharmaForensic Toxicology Lab, Institute of Forensic Sciences and Criminology, Panjab University, Chandigarh, India.
Panjab University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveMethylphenidate (MPH) is a first-line treatment option for attention-deficit hyperactive disorder and narcolepsy. MPH is one of the most abused psychostimulants by the adults and young population to stay awake, perform better, or improve concentration. The scanty reports say that the medical users or abusers mostly consider the administration of benzodiazepines to overcome the adverse effects, i.e., mood- and anxiety-related problems associated with MPH chronic abuse. This work aims to study the effect of alprazolam (ALZ) on MPH-associated adverse effects on liver and kidney. MATERIALS AND

methodsFemale Wistar rats (

resultsALZ, along with MPH, increased the serum alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, creatinine, and urea levels. The co-abuse also led to elevated oxidative stress and structural abnormalities in the liver and kidney tissues.

conclusionThe co-abuse of ALZ has amplified the hepato-renal toxic effects of MPH. Therefore, it is a significant concern for public safety, and their co-abuse must be restricted and discouraged.

Indexed as

AlprazolamAnimalsCentral Nervous System StimulantsDisease Models, AnimalFemaleHypnotics and SedativesKidneyLiverMethylphenidateOxidative StressRats, WistarSubstance-Related DisordersAlprazolamCentral Nervous System StimulantsHypnotics and SedativesMethylphenidateAdverse effectsbenzodiazepineoxidative stresspolydrug abusepsychostimulant

Identifiers

PMID32874006
PMCPMC7446684
OpenAlexW3046991741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.