ArticleNature communications2020
Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- SARS-CoV-2 seroprevalence around the world: an updated systematic review and meta-analysis.European journal of medical research · 2022Pooled it
- Children's role in the COVID-19 pandemic: a systematic review of early surveillance data on susceptibility, severity, and transmissibility.Scientific reports · 2021Pooled it
- Pooled it
- Trial
- Trial
- Genomic diversity of SARS-CoV-2 carriage in a cohort of schoolchildren in Côte d'ivoire during COVID-19 pandemics: insights from pre-delta emergence.BMC infectious diseases · 2026Article
- Kinetics and Durability of Antibody and T-Cell Responses to SARS-CoV-2 in Children.The Journal of infectious diseases · 2024Article
- Hybrid Immunity to SARS-CoV-2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection Alone.The Journal of infectious diseases · 2024Article
- Paediatric healthcare and hospital worker SARS-CoV-2 IgG antibody: A longitudinal cohort study.IJID regions · 2023Article
- SARS-CoV-2 Serostatus and COVID-19 Illness Characteristics by Variant Time Period in Non-Hospitalized Children and Adolescents.Children (Basel, Switzerland) · 2023Article
- COVID-19 Seroprevalence in Children during Pandemic Waves in Sarajevo, a Single Center Experience.Acta medica academica · 2023Article
- Comparison of nucleocapsid and spike antibody ELISAs for determining SARS-CoV-2 seropositivity in Kenyan women and infants.Journal of medical virology · 2023Article
- Leveraging CTSA hubs for rapid, large-scale, high-impact research: A case study during a global public health emergency.Journal of clinical and translational science · 2023Article
- Article
- Article
- Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2.bioRxiv : the preprint server for biology · 2022Article
- Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021.Nature communications · 2022Article
- The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes.PLoS pathogens · 2022Article
- The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes.bioRxiv : the preprint server for biology · 2022Article
- A SARS-CoV-2 variant elicits an antibody response with a shifted immunodominance hierarchy.PLoS pathogens · 2022Article
Corrections and comments
- Update of
Authors and funding
20 authors at 5 institutions in 2 countries.
Funding
Abstract
Children are strikingly underrepresented in COVID-19 case counts. In the United States, children represent 22% of the population but only 1.7% of confirmed SARS-CoV-2 cases as of April 2, 2020. One possibility is that symptom-based viral testing is less likely to identify infected children, since they often experience milder disease than adults. Here, to better assess the frequency of pediatric SARS-CoV-2 infection, we serologically screen 1,775 residual samples from Seattle Children's Hospital collected from 1,076 children seeking medical care during March and April of 2020. Only one child was seropositive in March, but seven were seropositive in April for a period seroprevalence of ≈1%. Most seropositive children (6/8) were not suspected of having had COVID-19. The sera of seropositive children have neutralizing activity, including one that neutralized at a dilution > 1:18,000. Therefore, an increasing number of children seeking medical care were infected by SARS-CoV-2 during the early Seattle outbreak despite few positive viral tests.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.