Evidence map›Paper›PMID 32873746›Full record

ArticleMolecular pharmacology2020

Enhancement of Muscimol Binding and Gating by Allosteric Modulators of the GABA

Gustav Akk, Allison L Germann, Yusuke Sugasawa, Spencer R Pierce, Alex S Evers, Joe Henry Steinbach

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Neurosteroid Modulation of GABACurrent neuropharmacology · 2022
    Article
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution.

Gustav AkkDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri akk@morpheus.wustl.edu.
Allison L GermannDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Yusuke SugasawaDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Spencer R PierceDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Alex S EversDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Joe Henry SteinbachDepartment of Anesthesiology (G.A., A.L.G., Y.S., S.R.P., A.S.E., J.H.S.) and the Taylor Family Institute for Innovative Psychiatric Research (G.A., A.S.E., J.H.S.), Washington University School of Medicine, St. Louis, Missouri.
Taylor Family Institute for Innovative Psychiatric Research

Funding

MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R01 GM108799
6 · The paper itself

Abstract

Muscimol is a psychoactive isoxazole derived from the mushroom

Indexed as

Allosteric RegulationBinding SitesGABA-A Receptor AgonistsHEK293 CellsHumansMultiprotein ComplexesMuscimolPregnanolonePregnenoloneReceptors, GABA-ARecombinant ProteinsSteroidsTritiumGABA-A Receptor AgonistsGABRA1 protein, humanGABRB3 protein, humanMultiprotein ComplexesMuscimolPregnanolonePregnenolonepregnenolone sulfateReceptors, GABA-ARecombinant ProteinsSteroidsTritium

Identifiers

PMID32873746
PMCPMC7472144
OpenAlexW3045950718

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.