Evidence map›Paper›PMID 32873649›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Engineering carboxylic acid reductase for selective synthesis of medium-chain fatty alcohols in yeast.

Yating Hu, Zhiwei Zhu, David Gradischnig, Margit Winkler, Jens Nielsen, Verena Siewers

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Review
  3. Directed evolution of hydrocarbon-producing enzymes.Biotechnology for biofuels and bioproducts · 2025
    Review
  4. High-throughput metabolic engineering ofProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Engineering yeast for tailored fatty acid profiles.Applied microbiology and biotechnology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeastProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  15. Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Yating HuDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.ORCID 0000-0001-5907-1135
Zhiwei ZhuDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
David GradischnigInstitute of Molecular Biotechnology, Graz University of Technology, A-8010 Graz, Austria.
Margit WinklerInstitute of Molecular Biotechnology, Graz University of Technology, A-8010 Graz, Austria.ORCID 0000-0002-0754-9704
Jens NielsenDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden; nielsenj@chalmers.se.ORCID 0000-0002-9955-6003
Verena SiewersDepartment of Biology and Biological Engineering, Chalmers University of Technology, SE-41296 Gothenburg, Sweden.
Chalmers University of Technology · SEInstitute of Molecular Biotechnology · ATDalian University of Technology · CNNovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medium-chain fatty alcohols (MCFOHs, C6 to C12) are potential substitutes for fossil fuels, such as diesel and jet fuels, and have wide applications in various manufacturing processes. While today MCFOHs are mainly sourced from petrochemicals or plant oils, microbial biosynthesis represents a scalable, reliable, and sustainable alternative. Here, we aim to establish a

Indexed as

AntiportersBiofuelsFatty AcidsFatty AlcoholsMetabolic EngineeringOrganic Cation Transport ProteinsOxidoreductasesProtein EngineeringSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAntiportersBiofuelscarboxylic acid reductaseFatty AcidsFatty AlcoholsOrganic Cation Transport ProteinsOxidoreductasesSaccharomyces cerevisiae Proteinscarboxylic acid reductasehigh-throughput screeningmedium-chain fatty alcoholsprotein engineeringSaccharomyces cerevisiae

Identifiers

PMID32873649
PMCPMC7502760
OpenAlexW3081793673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.