ArticleProceedings of the National Academy of Sciences of the United States of America2020
Kinetic profiling of metabolic specialists demonstrates stability and consistency of in vivo enzyme turnover numbers.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed.
- Predicting Enzyme Turnover Numbers and Enabling Rational Enzyme Evolution.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Integrative machine learning approaches for enzyme kinetic parameter prediction.Briefings in bioinformatics · 2026Review
- Accurate prediction of flux distributions compatible with metabolite concentration effects in genome-scale metabolic networks.PLoS computational biology · 2026Article
- Kinetic sampling shows the effect of medium composition on metabolic control in Saccharomyces cerevisiae.Microbial cell factories · 2026Article
- Machine learning for enzyme catalytic activity: current progress and future horizons.Briefings in bioinformatics · 2026Review
- A compact model of Escherichia coli core and biosynthetic metabolism.PLoS computational biology · 2025Article
- Algebraic differentiation for fast sensitivity analysis of optimal flux modes in metabolic models.Bioinformatics (Oxford, England) · 2025Article
- RBC-GEM: A genome-scale metabolic model for systems biology of the human red blood cell.PLoS computational biology · 2025Article
- An integrated structural and biophysical approach to study carbon metabolism inQRB discovery · 2025Review
- Combining systems and synthetic biology for in vivo enzymology.The EMBO journal · 2024Article
- Harnessing the optimization of enzyme catalytic rates in engineering of metabolic phenotypes.PLoS computational biology · 2024Article
- Integration of proteomic data with genome-scale metabolic models: A methodological overview.Protein science : a publication of the Protein Society · 2024Review
- Machine learning of metabolite-protein interactions from model-derived metabolic phenotypes.NAR genomics and bioinformatics · 2024Article
- Discretised Flux Balance Analysis for Reaction-Diffusion Simulation of Single-Cell Metabolism.Bulletin of mathematical biology · 2024Article
- Reconstruction, simulation and analysis of enzyme-constrained metabolic models using GECKO Toolbox 3.0.Nature protocols · 2024Review
- Enzyme catalytic efficiency prediction: employing convolutional neural networks and XGBoost.Frontiers in artificial intelligence · 2024Article
- DLTKcat: deep learning-based prediction of temperature-dependent enzyme turnover rates.Briefings in bioinformatics · 2023Article
- Genome-scale metabolic models reveal determinants of phenotypic differences in non-Saccharomyces yeasts.BMC bioinformatics · 2023Article
- Functional annotation of enzyme-encoding genes using deep learning with transformer layers.Nature communications · 2023Article
- A multi-scale expression and regulation knowledge base for Escherichia coli.Nucleic acids research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Enzyme turnover numbers (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.