ArticleBMJ open2020
Constipation and risk of cardiovascular diseases: a Danish population-based matched cohort study.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Pooled it
- Fiber intake and laxation in people with normal bowel function: a systematic review.The American journal of clinical nutrition · 2026Pooled it
- Association between constipation and risk of stroke: a systematic review and meta-analysis.Frontiers in neurology · 2025Pooled it
- Evaluating the Effect ofNutrients · 2024Trial
- Constipation prevalence and risk from prescribed medications in people with intellectual disability: Findings from an English mortality programme.Journal of intellectual disabilities : JOID · 2026Article
- Constipation: More Than a Quality-of-Life Issue.JACC. Asia · 2026Article
- Constipation and Incident Cardiovascular Disease: A Nationwide, Real-World Cohort Study.JACC. Asia · 2026Article
- Defecation Patterns and Cardiovascular Outcomes in Acute Coronary Syndrome: The Influence of Stimulant Laxative Use.JACC. Asia · 2026Article
- Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.Gut microbes · 2025Article
- Forensic considerations in cases of fatal constipation.Forensic science, medicine, and pathology · 2025Review
- Association between magnesium oxide use and readmission risk in patients with heart failure and constipation.Journal of pharmaceutical health care and sciences · 2025Article
- The inseparable relationship between constipation and blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Identifying risk factors associated with the health-related quality of life for coronary heart diseases elderly using association rule mining.Scientific reports · 2025Article
- Association between constipation and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies.Frontiers in cardiovascular medicine · 2025Review
- Constipation and risk of death and cardiovascular events in patients on hemodialysis.Kidney research and clinical practice · 2025Article
- Insomnia, pruritus, and constipation in hemodialysis patients: a cross-sectional study.Frontiers in physiology · 2025Article
- Risk factors of preoperative bowel dysfunction in acute Stanford B aortic dissection.American journal of translational research · 2025Article
- [Risk factors of recurrence of acute ischemic stroke and construction of a nomogram model for predicting the recurrence risk based on Lasso Regression].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Impact of Constipation on Health Outcomes in Medically Hospitalized Patients: A Prospective Study on Laxative Use and Health Care Outcomes.Medicina (Kaunas, Lithuania) · 2024Article
- Effective process quality control management for constipation prevention in hospitalized patients with acute coronary syndrome: An observational study.Health science reports · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the risks of myocardial infarction, stroke, peripheral artery disease, venous thromboembolism, atrial fibrillation or atrial flutter and heart failure in patients with constipation compared with a general population cohort.
designPopulation-based matched cohort study.
settingAll Danish hospitals and hospital outpatient clinics from 2004 to 2013.
participantsPatients with a constipation diagnosis matched on age, sex and calendar year to 10 individuals without constipation from the general population. MAIN OUTCOMES MEASURES: Comorbidity-adjusted and medication-adjusted hazard ratios (aHRs) for cardiovascular outcomes based on Cox regression analysis.
results83 239 patients with constipation were matched to 832 384 individuals without constipation. The median age at constipation diagnosis was 46.5% and 41% were men. Constipation was strongly associated with venous thromboembolism (aHR 2.04, 95% CI 1.89 to 2.20), especially splanchnic venous thrombosis (4.23, 95% CI 2.45 to 7.31). Constipation was also associated with arterial events, including myocardial infarction (1.24, 95% CI 1.14 to 1.35), ischaemic stroke (1.50, 95% CI 1.41 to 1.60), haemorrhagic stroke (1.46, 95% CI 1.26 to 1.69), peripheral artery disease (1.34, 95% CI 1.20 to 1.50), atrial fibrillation or atrial flutter (1.27, 95% CI 1.20 to 1.34) and heart failure (1.52, 95% CI 1.42 to 1.62). The associations were strongest during the first year after the constipation diagnosis and strengthened with an increased number of laxative prescriptions.
conclusionsConstipation was associated with an increased risk of several cardiovascular diseases, in particular venous thromboembolism.
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