Evidence map›Paper›PMID 32873612›Full record

ArticlemSystems2020

Respiratory Bacteria Stabilize and Promote Airborne Transmission of Influenza A Virus.

Hannah M Rowe, Brandi Livingston, Elisa Margolis, Amy Davis, Victoria A Meliopoulos, Haley Echlin, Stacey Schultz-Cherry, Jason W Rosch

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Direct interaction between avian pathogenicMicrobiology spectrum · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hannah M RoweDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Brandi LivingstonDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Elisa MargolisDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Amy DavisDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Victoria A MeliopoulosDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Haley EchlinDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
Stacey Schultz-CherryDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA Stacey.Schultz-Cherry@stjude.org Jason.Rosch@stjude.org.ORCID https://orcid.org/0000-0002-2021-727X
Jason W RoschDepartment of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA Stacey.Schultz-Cherry@stjude.org Jason.Rosch@stjude.org.ORCID https://orcid.org/0000-0002-1798-1760
St. Jude Children's Research Hospital · US

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
Pneumococcal pathogenesis in sickle cell diseaseR01AI110618 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI ROSCH, JASON W. · 2015 to 2019
$2.2M
NIAID NIH HHS HHSN272201400006CNIAID NIH HHS R01 AI110618NIAID NIH HHS U01 AI124302
6 · The paper itself

Abstract

Influenza A virus (IAV) is a major pathogen of the human respiratory tract, where the virus coexists and interacts with bacterial populations comprising the respiratory tract microbiome. Synergies between IAV and respiratory bacterial pathogens promote enhanced inflammation and disease burden that exacerbate morbidity and mortality. We demonstrate that direct interactions between IAV and encapsulated bacteria commonly found in the respiratory tract promote environmental stability and infectivity of IAV. Antibiotic-mediated depletion of the respiratory bacterial flora abrogated IAV transmission in ferret models, indicating that these virus-bacterium interactions are operative for airborne transmission of IAV. Restoring IAV airborne transmission in antibiotic-treated ferrets by coinfection with

Indexed as

microbiomeStreptococcus pneumoniaetransmission

Identifiers

PMID32873612
PMCPMC7470989
OpenAlexW3082498297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.