ArticleDigestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2021
Systemic inflammation as fuel for acute liver injury in COVID-19.
Article in Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- Liver injury associated with the severity of COVID-19: A meta-analysis.Frontiers in public health · 2023Pooled it
- Associations between Serum Interleukins (IL-1BioMed research international · 2022Pooled it
- Markers for the Severity of Multisystem Inflammatory Syndrome in Children: A Multivariate Analysis.International journal of pediatrics · 2026Article
- Association of inflammatory markers with abnormal liver biochemistry in hospitalized patients with COVID-19: a cross-sectional study.Frontiers in public health · 2026Article
- Resolved HBV infection is an independent risk factor for enhanced systemic inflammatory responses in COVID-19 patients.Frontiers in medicine · 2026Article
- Multiscale bone remodeling in COVID-19: from osteoimmune signaling to structural and mechanical impairment.Frontiers in bioengineering and biotechnology · 2026Review
- Review
- Lactate/albumin ratio predicts mortality in critically ill COVID-19 patients: a retrospective machine learning study.Scientific reports · 2025Article
- Hepatoprotective effects ofIranian journal of basic medical sciences · 2025Article
- Determinants of abnormal liver-related biomarkers in adult COVID-19 patients.Frontiers in cellular and infection microbiology · 2025Article
- Detection of SARS-CoV-2 Viral Genome and Viral Nucleocapsid in Various Organs and Systems.International journal of molecular sciences · 2024Article
- Clinical characteristics and the role of IL-6 in acute-on-chronic liver failure patients with or without COVID-19: a multicenter paired cohort study.Frontiers in cellular and infection microbiology · 2024Article
- Article
- The Liver Can Deliver: Utility of Hepatic Function Tests as Predictors of Outcome in COVID-19, Influenza and RSV Infections.Journal of clinical medicine · 2023Article
- COVID-19 induced liver injury from a new perspective: Mitochondria.Mitochondrion · 2023Review
- Liver injury at admission and outcomes in patients with COVID-19 disease: a prospective cohort study.Annals of medicine and surgery (2012) · 2023Article
- COVID-19 and hepatic injury: cellular and molecular mechanisms in diverse liver cells.World journal of gastroenterology · 2023Review
- SARS-CoV-2 Establishes a Productive Infection in Hepatoma and Glioblastoma Multiforme Cell Lines.Cancers · 2023Article
- COVID-19: Has the Liver Been Spared?International journal of molecular sciences · 2023Review
- Pathogenetic Mechanisms of Liver-Associated Injuries, Management, and Current Challenges in COVID-19 Patients.Biomolecules · 2023Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA cytokine storm conceivably contributes to manifestations of corona virus disease (COVID-19). Inflammatory cytokines such as interleukin-6 (IL-6) cause acute liver injury while serum detectability indicates systemic inflammation.
aimsWe explored a link between systemic IL-6, related acute phase proteins and liver injury in hospitalized COVID-19 patients.
methods655 patients with suspected COVID-19 were screened in the emergency department at the University Hospital of Innsbruck, Austria, between February and April 2020. 96 patients (∼15%) were hospitalized with COVID-19. 15 patients required intensive-care treatment (ICT). Plasma aminotransferases, alkaline phosphatase, bilirubin, and gamma glutamyl transferase, as well as IL-6, C-reactive protein (CRP), ferritin and lactate dehydrogenase (LDH) were determined by standard clinical assays.
resultsOf all hospitalized COVID-19 patients, 41 (42%) showed elevated aspartate aminotransferase (AST) concentration. COVID-19 patients with elevated AST exhibited significantly higher IL-6 (p < 0.001), ferritin (p < 0.001), LDH (p < 0.001) and CRP (p < 0.05) serum concentrations compared to patients with normal AST. Liver injury correlated with systemic IL-6 (p < 0.001), CRP (p < 0.001), ferritin (p < 0.001) and LDH (p < 0.001) concentration. In COVID-19 patients requiring ICT, correlations were more pronounced.
conclusionSystemic inflammation could be a fuel for hepatic injury in COVID-19.
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