Evidence map›Paper›PMID 32873404›Full record

ArticleVaccine2020

Effectiveness of the 10-valent pneumococcal conjugate vaccine against radiographic pneumonia among children in rural Bangladesh: A case-control study.

Eric D McCollum, Salahuddin Ahmed, Arun D Roy, Nabidul H Chowdhury, Holly B Schuh, Syed J R Rizvi, Abu A M Hanif, Ahad M Khan, Arif Mahmud, Farhan Pervaiz and 10 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06176664 (Oxygen Therapy for Children With Moderate Hypoxemia in Malawi), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06176664 nacompletednot on this mapstarted 2024, after this paper: background citation

Oxygen Therapy for Children With Moderate Hypoxemia in Malawi: Pilot Randomized Control Trial

TypeinterventionalSponsorJohns Hopkins UniversityRan2024 to 2024Enrolled21ConditionsPneumoniaArmsLow flow oxygen, High-flow nasal cannula oxygen
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Eric D McCollumGlobal Program in Respiratory Sciences, Eudowood Division of Pediatric Respiratory Sciences, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, USA; Health Systems Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA. Electronic address: emccoll3@jhmi.edu.
Salahuddin AhmedJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Arun D RoyJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Nabidul H ChowdhuryJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Holly B SchuhHealth Systems Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Syed J R RizviJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Abu A M HanifJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Ahad M KhanJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Arif MahmudJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Farhan PervaizGlobal Disease Epidemiology and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Meagan HarrisonHealth Systems Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Megan E RellerDivision of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA; Duke Hubert-Yeargan Center for Global Health, Durham, NC, USA; Duke Global Health Institute, Durham, NC, USA.
Nicole SimmonsGlobal Disease Epidemiology and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Abdul QuaiyumMaternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.
Nazma BegumJohns Hopkins University - Bangladesh, Dhaka, Bangladesh.
Mathuram SantoshamHealth Systems Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
William CheckleyGlobal Disease Epidemiology and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA; Division of Pulmonary and Critical Care, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Lawrence H MoultonGlobal Disease Epidemiology and Control Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Abdullah H BaquiHealth Systems Program, Department of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Projahnmo Study Group in Bangladesh
Johns Hopkins University · USCenter for Global Health · USInternational Centre for Diarrhoeal Disease Research · BDJohns Hopkins Medicine · US

Funding

Pulse oximetry for childhood pneumonia in rural BangladeshK01TW009988 · FIC · JOHNS HOPKINS UNIVERSITY · PI MCCOLLUM, ERIC DOUGLASS · 2014 to 2018
$704k
FIC NIH HHS K01 TW009988
6 · The paper itself

Abstract

backgroundPneumococcal conjugate vaccine (PCV) effectiveness against radiographic pneumonia in South Asia is unknown. Bangladesh introduced PCV10 in 2015 using a three dose primary series (3 + 0). We sought to measure PCV10 effectiveness for two or more vaccine doses on radiographic pneumonia among vaccine-eligible children in rural Bangladesh.

methodsWe conducted a matched case-control study over two years from 2015 to 2017 using clinic and community controls in three subdistricts of Sylhet, Bangladesh. Cases were vaccine eligible 3-35 month olds at Upazila Health Complex outpatient clinics with World Health Organization-defined radiographic primary endpoint pneumonia (radiographic pneumonia). Clinic controls were matched to cases within a one week time window by age, sex, and clinic and had an illness unlikely to be Streptococcus pneumoniae; community controls were healthy and similarly matched within a one week time window by age and sex, and distance from the clinic. We estimated adjusted vaccine effectiveness (aVE) using conditional logistic regression.

resultsWe matched 1262 cases with 2707 clinic and 2461 community controls. Overall, aVE using clinic controls was 21.4% (95% confidence interval, -0.2%, 38.4%) for ≥2 PCV10 doses and among 3-11 month olds was 47.3% (10.5%, 69.0%) for three doses. aVE increased with higher numbers of doses in clinic control sets (p = 0.007). In contrast, aVE using community controls was 7.6% (95% confidence interval, -22.2%, 30.0%) for ≥2 doses. We found vaccine introduction in the study area faster and less variable than expected with 75% coverage on average, which reduced power. Information bias may also have affected community controls.

conclusionsClinic control analyses show PCV10 prevented radiographic pneumonia in Bangladesh, especially among younger children receiving three doses. While both analyses were underpowered, community control enrollment - compared to clinic controls - was more difficult in a complex, pluralistic healthcare system. Future studies in comparable settings may consider alternative study designs.

Indexed as

Pneumococcal InfectionsPneumoniaPneumonia, PneumococcalAsiaBangladeshCase-Control StudiesChildHumansInfantPneumococcal VaccinesVaccines, Conjugate10-valent pneumococcal conjugate vaccinePneumococcal VaccinesVaccines, ConjugateAsiaBangladeshChildInfantPneumococcal vaccinesRadiographyRespiratory tract infections

Identifiers

PMID32873404
PMCPMC7520553
OpenAlexW3081520385

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.