Evidence map›Paper›PMID 32873278›Full record

ArticleBMC psychiatry2020

Associations between (sub) clinical stress- and anxiety symptoms in mentally healthy individuals and in major depression: a cross-sectional clinical study.

Georgia Konstantopoulou, Theodoros Iliou, Katerina Karaivazoglou, Gregoris Iconomou, Konstantinos Assimakopoulos, Panagiotis Alexopoulos

Open access · goldAbstract read
In one paragraph

Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
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  6. Observational
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  9. Stress Management in Athletes: Predictive Effects of Sleep Deprivation-Induced Cognitive Control Changes on Competition Performance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
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  20. Anxiety and Stress-Related Disorders.Focus (American Psychiatric Publishing) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Georgia KonstantopoulouSpecial Office for Health Consulting Services and Faculty of Education and Social Work, School of Humanities and Social Sciences, University of Patras, University of Patras Rion Campus, Rion Patras, 26504, Patras, Greece.
Theodoros IliouMedical Informatics Laboratory, Faculty of Medicine, School of Health Sciences, Democritus University of Thrace, Alexandroupolis Campus, 6th km Alexadroupolis - Makris (Dragana), Alexandroupolis, Greece.
Katerina KaraivazoglouChild and Adolescent Psychiatrist, Day Centre for Children with Autism Spectrum and other Developmental Disorders, K. Tzavela 12, 30200, Messolonghi, Greece.
Gregoris IconomouDepartment of Psychiatry, Patras University General Hospital, Faculty of Medicine, School of Health Sciences, University of Patras, PGNP 26504, Rion, Patras, Greece.
Konstantinos AssimakopoulosDepartment of Psychiatry, Patras University General Hospital, Faculty of Medicine, School of Health Sciences, University of Patras, PGNP 26504, Rion, Patras, Greece.
Panagiotis AlexopoulosDepartment of Psychiatry, Patras University General Hospital, Faculty of Medicine, School of Health Sciences, University of Patras, PGNP 26504, Rion, Patras, Greece. panos.alexopoulos@upatras.gr.ORCID 0000-0002-9047-6365
University of Patras · GRDemocritus University of Thrace · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResponses to stressful circumstances have psychological and physiological dimensions, and are related to anxiety symptoms and mental disorders such as depression. Nonetheless, the relationship between subclinical stress and anxiety symptoms is still elusive.

methodsTo explore possible associations between stress and anxiety symptoms, patients with major depression (N = 77) and mentally healthy individuals of different age clusters and occupations (N = 412) were enrolled into the study. Stress was assessed with the new subclinical stress symptom questionnaire (SSQ-25). Anxiety was studied with the Beck Anxiety Inventory (BAI), mainly focusing on clinical anxiety, whilst anxiety as a personality trait was assessed with the trait aspect of the State Τrait Αnxiety Ιnventory Y (STAI Y). Statistical analyses included ANOVA, Scheffe test, linear regression models and a two-step cluster analysis using Log-Likelihood Distance measure and fixed number of two clusters.

resultsAge, stress symptoms and BAI scores differed significantly between among groups (P < 0.001), whilst STAI Y scores did not. Stress levels were found to be related to clinical anxiety (P < 0.001), while neither group identity nor age exerted any influence on anxiety levels (P > 0.05). The two Step Cluster analysis classified 76 out of 77 participants with milder stress (subclinical) symptoms into the cluster with moderate anxiety, as indicated by BAI scores, and all individuals with more severe stress into the severe anxiety cluster.

conclusionsThe observed associations between stress and anxiety shed light on the interrelations between even very mild (subclinical) stress and anxiety symptoms and may point to the potential of mild stress to serve as a target for early interventions aiming to prevent anxiety morbidity.

Indexed as

DepressionMajor Depressive DisorderAnxietyAnxiety DisordersCross-Sectional StudiesHumansBeck anxiety inventoryPositive associationSubclinical stress symptom questionnaire-25

Identifiers

PMID32873278
PMCPMC7466802
OpenAlexW3082499324

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.