Evidence map›Paper›PMID 32873255›Full record

ArticleBMC immunology2020

Elevated expansion of follicular helper T cells in peripheral blood from children with acute measles infection.

Weiyun Shen, Hongzhou Ye, Xilin Zhang, Lixia Huo, Jingli Shen, Li Zhu, Xiang Wang, Dawei Cui

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Clinical utility of measuring CD4Journal of autoimmunity · 2023
    Article
  3. Article
  4. Immune Checkpoint Molecules Expressed on CD4Frontiers in microbiology · 2022
    Article
  5. Chromatin Modifications in 22q11.2 Deletion Syndrome.Journal of clinical immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Weiyun ShenKey Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Hongzhou YeDepartment of Paediatrics, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Xilin ZhangKey Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Lixia HuoKey Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Jingli ShenKey Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Li ZhuDepartment of Paediatrics, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Xiang WangKey Laboratory for Translational Medicine, First Affiliated Hospital, Huzhou Teachers College, the First People's Hospital of Huzhou, Huzhou, 313000, China.
Dawei CuiDepartment of Blood Transfusion, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, Zhejiang, China. cuidawei1978@163.com.ORCID 0000-0003-3840-1486
Huzhou University · CNBlood Center of Zhejiang Province · CN

Funding

Natural Science Foundation of Zhejiang Province LY16H200001Scientific Research Projects of Education of Zhejiang Province Y201534117
6 · The paper itself

Abstract

backgroundMeasles outbreaks have threatened the global elimination and eradication of measles in recent years. Measles virus (MeV)-specific antibodies are successful in clearing MeV infection. Follicular helper T (Tfh) cells play a crucial role in promoting antibody production. This study investigated the potential role of Tfh cells in peripheral blood mononuclear cells (PBMCs) from children with acute MeV infection.

resultsThe frequencies of CXCR5

conclusionThese results suggest that an elevated Tfh cell frequency and associated molecules possibly play a key role in children with acute MeV infection, which contributes to the prevention and treatment of MeV infection in children.

Indexed as

Acute DiseaseAntibodies, NeutralizingAntibodies, ViralCell ProliferationChild, PreschoolCytokinesFemaleGerminal CenterHumansInducible T-Cell Co-Stimulator ProteinInfantMaleMeaslesMeasles virusProgrammed Cell Death 1 ReceptorReceptors, CXCR5Antibodies, NeutralizingAntibodies, ViralCXCR5 protein, humanCytokinesICOS protein, humanInducible T-Cell Co-Stimulator ProteinPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, CXCR5Bcl-6Follicular helper T cellsIL-21Measles virusNeutralizing antibody

Identifiers

PMID32873255
PMCPMC7466526
OpenAlexW3082034601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.