Evidence map›Paper›PMID 32873246›Full record

ArticleBMC nephrology2020

Effect of donor non-muscle myosin heavy chain (MYH9) gene polymorphisms on clinically relevant kidney allograft dysfunction.

Joanna Pazik, Monika Oldak, Dominika Oziębło, Dominika Dęborska Materkowska, Anna Sadowska, Jacek Malejczyk, Magdalena Durlik

Open access · goldAbstract read
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In one paragraph

Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 83% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Joanna PazikDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006, Warsaw, Poland. jt.pazik@gmail.com.ORCID 0000-0001-9757-4382
Monika OldakDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Dominika OziębłoDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Dominika Dęborska MaterkowskaDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006, Warsaw, Poland.
Anna SadowskaDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006, Warsaw, Poland.
Jacek MalejczykDepartment of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.
Magdalena DurlikDepartment of Transplantation Medicine, Nephrology and Internal Diseases, Medical University of Warsaw, 59 Nowogrodzka Street, 02-006, Warsaw, Poland.
Medical University of Warsaw · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyższego NN402426633, NN402566850
6 · The paper itself

Abstract

backgroundDespite its established association with chronic kidney disease (CKD) the role of myosin-9 (MYH9) gene variation on transplanted kidney function remains unknown. This study aimed at evaluating the effect of donor MYH9 nephrogenic variants on renal allograft function within the first post transplantation year.

methodsIn the longitudinal kidney transplant study 207 deceased donors were genotyped for previously known risk MYH9 single nucleotide polymorphisms (SNPs). The predictor was MYH9 high-risk variants status. The primary outcome was mean eGFR found in low vs. high risk MYH9 genotypes between third and twelfth post-transplant month, the secondary outcome was the risk of proteinuria.

resultsDistribution of genotypes remained in Hardy-Weinberg equilibrium. The T allele of rs3752462 (dominant model, TT or TC vs. CC) was associated with higher filtration rate (P = 0.05) in a multivariate analysis after adjusting for delayed graft function and donor sex. Two G alleles of rs136211 (recessive model, GG vs. GA or AA) resulted in doubling the risk of proteinuria (OR = 2.22; 95% CI = 1.18-4.37, P = 0.017) after adjusting for donor and recipient sex.

conclusionDeceased donor kidneys of European descent harboring MYH9 SNPs rs3752462 T allele show significantly superior estimated filtration rate while those of rs136211 GG genotype excessive risk of proteinuria. These findings, if replicated, may further inform and improve individualization of allocation and treatment policies.

Indexed as

Glomerular Filtration RateKidney TransplantationAdolescentAdultAgedCadaverFemaleGenotypeHumansKidney Failure, ChronicLongitudinal StudiesMaleMiddle AgedMyosin Heavy ChainsPolymorphism, Single NucleotidePostoperative ComplicationsMYH9 protein, humanMyosin Heavy ChainsEstimated glomerular filtration rateGenetic biomarkerKidney transplantationMYH9ProteinuriaSNP

Identifiers

PMID32873246
PMCPMC7465840
OpenAlexW3082333833

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